Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma

Analysis of polymorphism at site -174 G/C of interleukin-6 promoter region in multiple myeloma

Autor Duch, Cibele Repele Autor UNIFESP Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Ribas, Christian Autor UNIFESP Google Scholar
Almeida, Manuella de Souza Sampaio Autor UNIFESP Google Scholar
Colleoni, Gisele Wally Braga Autor UNIFESP Google Scholar
Bordin, Jose Orlando Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo It is well established that interleukin-6 (IL-6) is an essential growth factor for multiple myeloma (MM) and patients with increased IL-6 levels have a poor prognosis. In healthy subjects, the presence of the C allele at a polymorphic site (-174 G/C) of the IL-6 gene is related to low IL-6 levels. In view of the potential association of this particular polymorphism with IL-6 concentration, and the relevance of IL-6 in MM pathogenesis, the objective of the present study was to investigate the prevalence of IL-6 (-174 G/C) promoter polymorphism and its association with development of MM in Brazilian individuals. We investigated the prevalence of these alleles in 52 patients and 60 healthy subjects (matched by age, sex, and race) of a Brazilian population. Thirty patients were male (42.4%), 24 (46.2%) were white and the median age at diagnosis was 58.5 years (range: 28 to 84 years). To determine the IL-6 (-174 G/C) polymorphism, molecular analysis was performed by polymerase chain reaction followed by endonuclease restriction digestion. The genotype distributions observed in the group of patients were 4% CC, 42% GC and 54% GG. The C allele frequency was 0.25. These results were similar to the control group, suggesting no impact of this polymorphism on the susceptibility to MM.
Palavra-chave Multiple myeloma
Interleukin-6
Polymorphisms
Idioma Inglês
Data de publicação 2007-02-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 2, p. 265-267, 2007.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 265-267
Fonte http://dx.doi.org/10.1590/S0100-879X2006005000067
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000243977400014
SciELO S0100-879X2007000200014 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/3510

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