Altered Glucose Homeostasis and Hepatic Function in Obese Mice Deficient for Both Kinin Receptor Genes

Altered Glucose Homeostasis and Hepatic Function in Obese Mice Deficient for Both Kinin Receptor Genes

Author Barros, Carlos C. Autor UNIFESP Google Scholar
Haro, Anderson Autor UNIFESP Google Scholar
Russo, Fernanda J. V. P. Autor UNIFESP Google Scholar
Schadock, Ines Google Scholar
Almeida, Sandro S. Autor UNIFESP Google Scholar
Ribeiro, Rosane A. Google Scholar
Vanzela, Emerielle C. Google Scholar
Lanzoni, Valeria Pereira Autor UNIFESP Google Scholar
Barros, Flavio C. Google Scholar
Moraes, Milton Rocha de Autor UNIFESP Google Scholar
Mori, Marcelo A. Autor UNIFESP Google Scholar
Bacurau, Reury Frank Pereira Google Scholar
Wurtele, Martin Autor UNIFESP Google Scholar
Boschero, Antonio C. Google Scholar
Carneiro, Everardo M. Google Scholar
Bader, Michael Google Scholar
Pesquero, João Bosco Autor UNIFESP Google Scholar
Araujo, Ronaldo C. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Max Delbruck Ctr Mol Med
Universidade Estadual de Campinas (UNICAMP)
Univ Estadual Paulista
Universidade de São Paulo (USP)
Abstract The Kallikrein-Kinin System (KKS) has been implicated in several aspects of metabolism, including the regulation of glucose homeostasis and adiposity. Kinins and des-Arg-kinins are the major effectors of this system and promote their effects by binding to two different receptors, the kinin B2 and B1 receptors, respectively. To understand the influence of the KKS on the pathophysiology of obesity and type 2 diabetes (T2DM), we generated an animal model deficient for both kinin receptor genes and leptin (obB1B2KO). Six-month-old obB1B2KO mice showed increased blood glucose levels. Isolated islets of the transgenic animals were more responsive to glucose stimulation releasing greater amounts of insulin, mainly in 3-month-old mice, which was corroborated by elevated serum C-peptide concentrations. Furthermore, they presented hepatomegaly, pronounced steatosis, and increased levels of circulating transaminases. This mouse also demonstrated exacerbated gluconeogenesis during the pyruvate challenge test. the hepatic abnormalities were accompanied by changes in the gene expression of factors linked to glucose and lipid metabolisms in the liver. Thus, we conclude that kinin receptors are important for modulation of insulin secretion and for the preservation of normal glucose levels and hepatic functions in obese mice, suggesting a protective role of the KKS regarding complications associated with obesity and T2DM.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2012-07-19
Published in Plos One. San Francisco: Public Library Science, v. 7, n. 7, 11 p., 2012.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent 11
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000306956300015

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