Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice

Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice

Author Eserian, Jaqueline Kalleian Autor UNIFESP Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Andersen, Monica Levy Autor UNIFESP Google Scholar
Fernandes Galduroz, Jose Carlos Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the objective of the present study was to assess whether the administration of polyunsaturated fatty acids (PUFAs) would lead to alterations in cocaine-conditioned place preference by correlating behavioral data and plasma levels of PUFAs.Methods: Five groups of C57Bl/6J mice received a linseed oil supplement or a control solution for 19 days and were conditioned to cocaine.Results: PUFAs did not exert a protective effect against cocaine-conditioned place-preference behavior, although there were significant differences in the levels of eicosapentaenoic acid (EPA) and linoleic acid among the groups tested. Higher doses of PUFAs might be necessary to induce a change in the plasma level of EPA in cocaine-conditioned mice.Discussion: PUFAs had no effect on cocaine-conditioned place preference.
Keywords Cocaine
Place preference
Polyunsaturated fatty acids
Language English
Date 2012-07-01
Published in Nutritional Neuroscience. Leeds: Maney Publishing, v. 15, n. 4, p. 171-175, 2012.
ISSN 1028-415X (Sherpa/Romeo, impact factor)
Publisher Maney Publishing
Extent 171-175
Origin http://dx.doi.org/10.1179/1476830512Y.0000000005
Access rights Closed access
Type Article
Web of Science ID WOS:000306436000003
URI http://repositorio.unifesp.br/handle/11600/35082

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