Tegafur-uracil is a safe alternative for the treatment of colorectal cancer in patients with partial dihydropyrimidine dehydrogenase deficiency: a proof of principle

Tegafur-uracil is a safe alternative for the treatment of colorectal cancer in patients with partial dihydropyrimidine dehydrogenase deficiency: a proof of principle

Author Cubero, Daniel I. G. Google Scholar
Cruz, Felipe Melo Google Scholar
Santi, Patricia Google Scholar
Silva, Ismael Dale C. G. Autor UNIFESP Google Scholar
del Giglio, Auro Google Scholar
Institution ABC Fdn Sch Med
Universidade Federal de São Paulo (UNIFESP)
Albert Einstein Jewish Hosp
Abstract Objective: the objective of this study was to evaluate the safety of using tegafur-uracil (UFT) in colorectal cancer patients with partial dihydropyrimidine dehydrogenase (DPD) deficiency.Patients and Methods: the study included five colorectal cancer patients who presented with acute toxicity (grades 3 and 4) after being given the first cycle of chemotherapy using 5-fluorouracil. the DPD deficiency was confirmed by gene sequencing. After a full recovery from all side effects, we changed the regimen to UFT (300 mg/m(2)/day) associated with leucovorin (90 mg/day) for 21 days, with an empirical dose reduction of at least 10% in the first cycle.Results: We prospectively analysed 22 UFT cycles in 5 patients. We did not observe any episodes of grade 3 or 4 toxicity. the predominant toxicities were of grades 1 and 2 (nausea, vomiting and diarrhoea).Conclusion: Here, we demonstrate a complete absence of severe toxicity in all patients and cycles analysed. We believe that UFT is a safe alternative for the treatment of patients with partial DPD deficiency.
Keywords colorectal neoplasms
dihydropyrimidine dehydrogenase deficiency
drug toxicity
fluorouracil
tegafur
uracil
Language English
Date 2012-07-01
Published in Therapeutic Advances in Medical Oncology. London: Sage Publications Ltd, v. 4, n. 4, p. 167-172, 2012.
ISSN 1758-8340 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 167-172
Origin http://dx.doi.org/10.1177/1758834012441049
Access rights Closed access
Type Article
Web of Science ID WOS:000208965400002
URI http://repositorio.unifesp.br/handle/11600/35081

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