Association of ACE Gene Insertion/Deletion Polymorphism With Birth Weight, Blood Pressure Levels, and ACE Activity in Healthy Children

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dc.contributor.author Ajala, Aline R. [UNIFESP]
dc.contributor.author Almeida, Sandro S. [UNIFESP]
dc.contributor.author Rangel, Marina [UNIFESP]
dc.contributor.author Palomino, Zaira [UNIFESP]
dc.contributor.author Strufaldi, Maria Wany L. [UNIFESP]
dc.contributor.author Puccini, Rosana F. [UNIFESP]
dc.contributor.author Araujo, Ronaldo C. [UNIFESP]
dc.contributor.author Casarini, Dulce Elena [UNIFESP]
dc.contributor.author Franco, Maria C. P. [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:26Z
dc.date.available 2016-01-24T14:27:26Z
dc.date.issued 2012-07-01
dc.identifier http://dx.doi.org/10.1038/ajh.2012.50
dc.identifier.citation American Journal of Hypertension. New York: Nature Publishing Group, v. 25, n. 7, p. 827-832, 2012.
dc.identifier.issn 0895-7061
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/35068
dc.description.abstract BACKGROUNDThe human angiotensin-converting enzyme (ACE) gene contains a polymorphism consisting of either an insertion (I) or a deletion (D) of a 287 bp Alu repetitive sequence in intron 16. the potential role of ACE polymorphism in the risk of developing hypertension or other cardiovascular disorders has not been determined in relation to birth weight (BW).METHODSThe ACE genotype and plasma ACE activity were determined in 167 children. Among these children, 60 were identified with low BW (LBW), and 107 were of normal BW (NBW).RESULTSACE activity levels were significantly elevated in LBW children compared with the NBW group (P < 0.001). There was a significant association of the ACE activity with systolic blood pressure (SBP) levels in our population (P < 0.001). Among the ACE genotypes, no significant differences were found with respect to BW (P = 0.136). However, our results revealed that LBW children had a higher D allele frequency than NBW children (P = 0.036). When analyzed by quartiles of SBP or ACE activity, we found a greater frequency of both the LBW children and those carrying the DD genotype in the highest quartiles of these parameters, whereas the NBW children tended to be in the lowest quartile (P < 0.001). Similar results were observed with the heterozygote ID children after categorization by quartiles of both SBP (P < 0.001) and ACE activity (P = 0.004).CONCLUSIONSThe ACE I/D polymorphism, especially the DD genotype, can be interpreted as a major factor in association between LBW and high BP levels. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 827-832
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof American Journal of Hypertension
dc.rights Acesso restrito
dc.subject ACE activity en
dc.subject ACE I/D polymorphism en
dc.subject birth weight en
dc.subject blood pressure en
dc.subject children en
dc.subject hypertension en
dc.title Association of ACE Gene Insertion/Deletion Polymorphism With Birth Weight, Blood Pressure Levels, and ACE Activity in Healthy Children en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biophys, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biophys, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, Dept Pediat, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2007/58044-2
dc.identifier.doi 10.1038/ajh.2012.50
dc.description.source Web of Science
dc.identifier.wos WOS:000305373700016



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