Allometric scaling of 6-min walking distance by body mass as a standardized measure of exercise capacity in healthy adults

Allometric scaling of 6-min walking distance by body mass as a standardized measure of exercise capacity in healthy adults

Author Dourado, Victor Zuniga Autor UNIFESP Google Scholar
McBurnie, Mary Ann Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Kaiser Permanente Ctr Hlth Res
Abstract Body mass (BM) is a confounding variable in human performance. We hypothesized that adjusting 6-min walk distance (6MWD) for BM differences using allometric scaling would allow meaningful individual and group comparisons. We aimed to use allometric scaling of 6MWD to BM to provide an index for comparing walking performance in middle-aged and older adults. One hundred and twenty subjects (40-87 years) participated. Anthropometry, spirometry, and two walk tests were evaluated. We adjusted 6MWD to BM, gender, and age using an allometric procedure. the allometric exponents were prospectively applied in a validation sample of 44 healthy subjects. Body mass presented significant negative correlation (p < 0.01) with 6MWD center dot A BM-1 in middle-aged and older adults (r = -0.70 and -0.46, respectively). the allometric exponent (b) for 6MWD was significantly higher for older than middle-aged adults (0.35 +/- A 0.20 vs. 0.11 +/- A 0.08, respectively). the resulting BM exponents were similar in male and female subjects (0.22 +/- A 0.13 and 0.17 +/- A 0.09, respectively). the correlation between 6MWD center dot A BM-b and BM using the exponents (0.11 or 0.35) was not statistically different from zero (r = 0.00) in the validation sample, suggesting that allometric analysis did not penalize the subjects based on BM. Allometric scaling of 6MWD in middle-aged and older adults may be useful for evaluating walking performance free of the confounding effect of BM, even in the absence of a table of norms.
Keywords Allometry
Healthy adults
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2007/08673-3
Date 2012-07-01
Published in European Journal of Applied Physiology. New York: Springer, v. 112, n. 7, p. 2503-2510, 2012.
ISSN 1439-6319 (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 2503-2510
Access rights Closed access
Type Article
Web of Science ID WOS:000305129300013

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