MspA1 polymorphism of the CYP17 gene in breast cysts

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dc.contributor.author Tote Franco Pinotti, Solange Cristina [UNIFESP]
dc.contributor.author Cotrim Guerreiro da Silva, Ismael Dale [UNIFESP]
dc.contributor.author Carvalho, Cristina Valeta [UNIFESP]
dc.contributor.author Pinto Nazario, Afonso Celso [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:21Z
dc.date.available 2016-01-24T14:27:21Z
dc.date.issued 2012-06-01
dc.identifier http://dx.doi.org/10.3109/09513590.2011.614115
dc.identifier.citation Gynecological Endocrinology. New York: Informa Healthcare, v. 28, n. 6, p. 443-446, 2012.
dc.identifier.issn 0951-3590
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34985
dc.description.abstract Objective: To study the prevalence of breast cysts in several age groups of the general female population and their association with the MspAI polymorphism of the gene CYP17. Results: in 204 ultrasound tests, cysts were present in 22% of the studied population. the epidemiological-clinical profile of these women was Caucasian, aged 41-50 years, regular menstrual cycles, multiparous and complaining of mastalgia. the genetic distribution of polymorphisms of the gene displayed Hardy-Weinberg equilibrium and the wild homozygous phenotype was observed in 36.4% of the case group and in 37.6% of the control groups; the heterozygous phenotype was observed in 50% of the study group and 46.3% of control group and a mutated homozygous phenotype was seen in 13.6% of the study group and 16.1% of the controls. There was no statistically significant difference between the groups (p = 0.92). Conclusion: the prevalence and most of the epidemiological profile of breast cysts were in agreement with the literature. There was no statistically significant difference among the genotypic groups (wild homozygous, heterozygous and mutated homozygous), despite a slightly increased frequency of the mutated genotype in the control group. This difference indicates a trend of the MspAI polymorphism of the gene CYP17 to act as a protective factor against the development of breast cysts. en
dc.format.extent 443-446
dc.language.iso eng
dc.publisher Informa Healthcare
dc.relation.ispartof Gynecological Endocrinology
dc.rights Acesso restrito
dc.subject Breast cyst en
dc.subject gene CYP17 en
dc.subject MspAI polymorphism en
dc.title MspA1 polymorphism of the CYP17 gene in breast cysts en
dc.type Artigo
dc.rights.license http://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Gynecol, Escola Paulista Med UNIFESP EPM, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Gynecol, Escola Paulista Med UNIFESP EPM, São Paulo, Brazil
dc.identifier.doi 10.3109/09513590.2011.614115
dc.description.source Web of Science
dc.identifier.wos WOS:000304067400009



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