MspA1 polymorphism of the CYP17 gene in breast cysts

MspA1 polymorphism of the CYP17 gene in breast cysts

Author Tote Franco Pinotti, Solange Cristina Autor UNIFESP Google Scholar
Cotrim Guerreiro da Silva, Ismael Dale Autor UNIFESP Google Scholar
Carvalho, Cristina Valeta Autor UNIFESP Google Scholar
Pinto Nazario, Afonso Celso Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To study the prevalence of breast cysts in several age groups of the general female population and their association with the MspAI polymorphism of the gene CYP17. Results: in 204 ultrasound tests, cysts were present in 22% of the studied population. the epidemiological-clinical profile of these women was Caucasian, aged 41-50 years, regular menstrual cycles, multiparous and complaining of mastalgia. the genetic distribution of polymorphisms of the gene displayed Hardy-Weinberg equilibrium and the wild homozygous phenotype was observed in 36.4% of the case group and in 37.6% of the control groups; the heterozygous phenotype was observed in 50% of the study group and 46.3% of control group and a mutated homozygous phenotype was seen in 13.6% of the study group and 16.1% of the controls. There was no statistically significant difference between the groups (p = 0.92). Conclusion: the prevalence and most of the epidemiological profile of breast cysts were in agreement with the literature. There was no statistically significant difference among the genotypic groups (wild homozygous, heterozygous and mutated homozygous), despite a slightly increased frequency of the mutated genotype in the control group. This difference indicates a trend of the MspAI polymorphism of the gene CYP17 to act as a protective factor against the development of breast cysts.
Keywords Breast cyst
gene CYP17
MspAI polymorphism
Language English
Date 2012-06-01
Published in Gynecological Endocrinology. New York: Informa Healthcare, v. 28, n. 6, p. 443-446, 2012.
ISSN 0951-3590 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 443-446
Origin http://dx.doi.org/10.3109/09513590.2011.614115
Access rights Closed access
Type Article
Web of Science ID WOS:000304067400009
URI http://repositorio.unifesp.br/handle/11600/34985

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