Immunohistochemical features of claudin-low intrinsic subtype in metaplastic breast carcinomas

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dc.contributor.author Gerhard, Rene
dc.contributor.author Ricardo, Sara
dc.contributor.author Albergaria, Andre
dc.contributor.author Gomes, Madalena
dc.contributor.author Silva, Alfredo Ribeiro
dc.contributor.author Logullo, Angela Flavia [UNIFESP]
dc.contributor.author Cameselle-Teijeiro, Jorge F.
dc.contributor.author Paredes, Joana
dc.contributor.author Schmitt, Fernando
dc.date.accessioned 2016-01-24T14:27:19Z
dc.date.available 2016-01-24T14:27:19Z
dc.date.issued 2012-06-01
dc.identifier http://dx.doi.org/10.1016/j.breast.2012.03.001
dc.identifier.citation Breast. Edinburgh: Churchill Livingstone, v. 21, n. 3, p. 354-360, 2012.
dc.identifier.issn 0960-9776
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34953
dc.description.abstract Purpose: the claudin-low molecular subtype of breast cancer includes triple negative invasive carcinomas, with a high frequency of metaplastic and medullary features. the aim of this study was to evaluate the immunohistochemistry expression of claudins in a series of metaplastic breast carcinomas. We also assessed other claudin-low features, such as the cancer stem cell-like and epithelial-to-mesenchymal transition phenotypes.Results: the majority of the cases showed weak or negative staining for membrane claudins expression. We found 76.9% (10/13) low expressing cases for claudin-1, 84.6% (11/13) for claudin-3 and claudin-4, and 92.3% (12/13) for claudin-7. Regarding the cancer stem cell marker ALDH1, 30.8% (4/13) showed positive staining. We also showed that the majority of the cases presented a CD44(+)CD24(-/low) phenotype, positivity for vimentin and lack of E-cadherin expression. Interestingly, these claudin-low molecular features were specific of the mesenchymal component of metaplastic breast carcinomas, since its frequency was very low in other breast cancer molecular subtypes, as luminal, HER2-overexpressing and non-metaplastic triple negative tumors.Conclusions: the negative/low expression of claudins and E-cadherin, high levels of vimentin, and the breast cancer stem cell phenotype suggests that metaplastic breast carcinomas have similar features to the ones included in the claudin-low molecular subtype, specially their mesenchymal components. (C) 2012 Elsevier B.V. All rights reserved. en
dc.description.sponsorship Fundacao Calouste Gulbenkian
dc.description.sponsorship Portuguese Science and Technology Foundation (FCT)
dc.description.sponsorship FEDER: Sistema de Incentivos a Investigacao e Desenvolvimento Tecnologico, Programa Operacional de Factores de Competitividade
dc.format.extent 354-360
dc.language.iso eng
dc.publisher Churchill Livingstone
dc.relation.ispartof Breast
dc.rights Acesso restrito
dc.subject Breast cancer en
dc.subject Metaplastic breast carcinoma en
dc.subject Claudins en
dc.subject Claudin-low subtype en
dc.title Immunohistochemical features of claudin-low intrinsic subtype in metaplastic breast carcinomas en
dc.type Artigo
dc.contributor.institution Univ Porto
dc.contributor.institution ICBAS Abel Salazar Biomed Sci Inst
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Complexo Hosp Univ Vigo CHUVI
dc.description.affiliation Univ Porto, IPATIMUP Inst Mol Pathol & Immunol, P-4100 Oporto, Portugal
dc.description.affiliation ICBAS Abel Salazar Biomed Sci Inst, Oporto, Portugal
dc.description.affiliation Univ São Paulo, Fac Med, Dept Pathol, BR-14049 Ribeirao Preto, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Sch Med, Dept Pathol, São Paulo, Brazil
dc.description.affiliation Complexo Hosp Univ Vigo CHUVI, Vigo, Spain
dc.description.affiliation Univ Porto, Fac Med, P-4100 Oporto, Portugal
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Sch Med, Dept Pathol, São Paulo, Brazil
dc.description.sponsorshipID SFRH/BPD/73247/2010
dc.description.sponsorshipID 13531
dc.identifier.doi 10.1016/j.breast.2012.03.001
dc.description.source Web of Science
dc.identifier.wos WOS:000306381500024



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