Immunohistochemical features of claudin-low intrinsic subtype in metaplastic breast carcinomas

Immunohistochemical features of claudin-low intrinsic subtype in metaplastic breast carcinomas

Author Gerhard, Rene Google Scholar
Ricardo, Sara Google Scholar
Albergaria, Andre Google Scholar
Gomes, Madalena Google Scholar
Silva, Alfredo Ribeiro Google Scholar
Logullo, Angela Flavia Autor UNIFESP Google Scholar
Cameselle-Teijeiro, Jorge F. Google Scholar
Paredes, Joana Google Scholar
Schmitt, Fernando Google Scholar
Institution Univ Porto
ICBAS Abel Salazar Biomed Sci Inst
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Complexo Hosp Univ Vigo CHUVI
Abstract Purpose: the claudin-low molecular subtype of breast cancer includes triple negative invasive carcinomas, with a high frequency of metaplastic and medullary features. the aim of this study was to evaluate the immunohistochemistry expression of claudins in a series of metaplastic breast carcinomas. We also assessed other claudin-low features, such as the cancer stem cell-like and epithelial-to-mesenchymal transition phenotypes.Results: the majority of the cases showed weak or negative staining for membrane claudins expression. We found 76.9% (10/13) low expressing cases for claudin-1, 84.6% (11/13) for claudin-3 and claudin-4, and 92.3% (12/13) for claudin-7. Regarding the cancer stem cell marker ALDH1, 30.8% (4/13) showed positive staining. We also showed that the majority of the cases presented a CD44(+)CD24(-/low) phenotype, positivity for vimentin and lack of E-cadherin expression. Interestingly, these claudin-low molecular features were specific of the mesenchymal component of metaplastic breast carcinomas, since its frequency was very low in other breast cancer molecular subtypes, as luminal, HER2-overexpressing and non-metaplastic triple negative tumors.Conclusions: the negative/low expression of claudins and E-cadherin, high levels of vimentin, and the breast cancer stem cell phenotype suggests that metaplastic breast carcinomas have similar features to the ones included in the claudin-low molecular subtype, specially their mesenchymal components. (C) 2012 Elsevier B.V. All rights reserved.
Keywords Breast cancer
Metaplastic breast carcinoma
Claudin-low subtype
Language English
Sponsor Fundacao Calouste Gulbenkian
Portuguese Science and Technology Foundation (FCT)
FEDER: Sistema de Incentivos a Investigacao e Desenvolvimento Tecnologico, Programa Operacional de Factores de Competitividade
Grant number SFRH/BPD/73247/2010
Date 2012-06-01
Published in Breast. Edinburgh: Churchill Livingstone, v. 21, n. 3, p. 354-360, 2012.
ISSN 0960-9776 (Sherpa/Romeo, impact factor)
Publisher Churchill Livingstone
Extent 354-360
Access rights Closed access
Type Article
Web of Science ID WOS:000306381500024

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