Atypical manifestations in Brazilian patients with neuro-Behcet's disease

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dc.contributor.author Dutra, Livia Almeida [UNIFESP]
dc.contributor.author Goncalves, Celio Roberto
dc.contributor.author Braga-Neto, Pedro [UNIFESP]
dc.contributor.author Pedroso, Jose Luiz [UNIFESP]
dc.contributor.author Gabbai, Alberto Alain [UNIFESP]
dc.contributor.author Barsottini, Orlando Graziani Povoas [UNIFESP]
dc.contributor.author Silva de Souza, Alexandre Wagner [UNIFESP]
dc.date.accessioned 2016-01-24T14:27:18Z
dc.date.available 2016-01-24T14:27:18Z
dc.date.issued 2012-06-01
dc.identifier http://dx.doi.org/10.1007/s00415-011-6319-z
dc.identifier.citation Journal of Neurology. Heidelberg: Springer Heidelberg, v. 259, n. 6, p. 1159-1165, 2012.
dc.identifier.issn 0340-5354
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34936
dc.description.abstract Type and frequency of systemic and neurologic manifestations of Beh double dagger et's disease (BD) vary with ethnicity. in Brazil, BD occurs as sporadic cases. We describe clinical and radiological features of 36 Brazilian patients of mixed ethnicity with neuro-Beh double dagger et's disease (NBD). Medical records of 178 BD patients were reviewed and 36 (20%) NBD patients were identified. Twenty-one NBD patients (58.3%) were female and 27 (75%) presented with parenchymal manifestations. Brainstem involvement was the most common neurologic syndrome (41.7%). Seizures (27.8%), isolated aseptic meningitis (16.7%), optic neuropathy (ON) (16.7%), cerebral venous thrombosis (CVT) (8.3%), peripheral neuropathy (2.8%), and spinal cord involvement (5.6%) were other neurologic manifestations observed among Brazilian NBD patients. Eighteen (50%) had at least one relapse, and isolated aseptic meningitis was the most common relapsing manifestation. No significant differences concerning the number of relapses between parenchymal and non-parenchymal groups were found. A multivariate model including disease duration, cell count in spinal fluid, cyclosporine use, immunosuppressive use at disease onset, age at NBD onset, and ON did not reveal any significant associations with NBD relapse. There was a low frequency of CVT and an unexpected higher number of isolated aseptic meningitis. Brazilian NBD patients present more parenchymal and atypical manifestations, and relapse more often than NBD patients from other populations. en
dc.format.extent 1159-1165
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Journal of Neurology
dc.rights Acesso restrito
dc.subject Behcet's syndrome en
dc.subject Neuro-Behcet's disease en
dc.subject Epilepsy en
dc.subject Peripheral neuropathy en
dc.subject Stroke en
dc.subject Cerebral venous thrombosis en
dc.subject Optic neuropathy en
dc.subject Demyelinating syndrome en
dc.title Atypical manifestations in Brazilian patients with neuro-Behcet's disease en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Hosp Israelita Albert Einstein
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Gen Neurol Div, Dept Neurol & Neurosurg, BR-04039002 São Paulo, Brazil
dc.description.affiliation Hosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa Albert Einstein, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Div Rheumatol, Dept Med, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Div Rheumatol, Dept Med, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Gen Neurol Div, Dept Neurol & Neurosurg, BR-04039002 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Div Rheumatol, Dept Med, BR-04039002 São Paulo, Brazil
dc.identifier.doi 10.1007/s00415-011-6319-z
dc.description.source Web of Science
dc.identifier.wos WOS:000304859300021



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