Exercise preconditioning modulates genotoxicity induced by doxorubicin in multiple organs of rats

Exercise preconditioning modulates genotoxicity induced by doxorubicin in multiple organs of rats

Author Martins, Renato Almeida Autor UNIFESP Google Scholar
Minari, Andre Luis Autor UNIFESP Google Scholar
Chaves, Marcelo Donizetti Autor UNIFESP Google Scholar
Thomatieli dos Santos, Ronaldo Wagner Autor UNIFESP Google Scholar
Barbisan, Luis Fernando Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract The aim of this study was to investigate the effects of exercise in multiple organs of rats treated with doxorubicin. Male adult Wistar rats were distributed into the following groups: sedentary + NaCl; exercise + NaCl; sedentary + doxorubicin; and exercise + doxorubicin. Animals were sacrificed 2?days following injections. Central fragments from heart, liver, and kidney were collected and minced in 0.9% NaCl being cellular suspensions used for the single-cell gel (comet) assay. the results showed that exercise was able to prevent genotoxicity induced by doxorubicin in heart cells. By contrast, exercise was not able to prevent genotoxicity induced by doxorubicin in liver cells. the same occurred to kidney cells, i.e. no statistically significant differences (p?>?0.05) were found when compared with groups not exposed to doxorubicin. Taken together, our results support the idea that exercise could contribute to the protective effect against genotoxicity induced by doxorubicin in heart cells. Copyright (c) 2012 John Wiley & Sons, Ltd.
Keywords exercise
single-cell gel (comet) assay
doxorubicin
DNA damage
rats
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Grant number CNPq: 561357/2008-0
Date 2012-06-01
Published in Cell Biochemistry and Function. Hoboken: Wiley-Blackwell, v. 30, n. 4, p. 293-296, 2012.
ISSN 0263-6484 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 293-296
Origin http://dx.doi.org/10.1002/cbf.2799
Access rights Closed access
Type Article
Web of Science ID WOS:000304863800006
URI http://repositorio.unifesp.br/handle/11600/34928

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