Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease

Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's disease

Author Fernandes, Valeria S. Google Scholar
Santos, Jose R. Google Scholar
Leao, Anderson H. F. F. Google Scholar
Medeiros, Andre M. Google Scholar
Melo, Thieza G. Google Scholar
Izidio, Geison S. Google Scholar
Cabral, Alicia Google Scholar
Ribeiro, Rosana A. Autor UNIFESP Google Scholar
Abilio, Vanessa C. Autor UNIFESP Google Scholar
Ribeiro, Alessandra M. Google Scholar
Silva, Regina H. Google Scholar
Institution Univ Fed Rio Grande do Norte
Universidade Federal de São Paulo (UNIFESP)
Abstract Animal models are widely used to study alterations caused by Parkinson's disease (PD). However, in general, pharmacological models do not express the progressive nature of the disease, being characterized by immediate severe motor impairment after a single dose of the drug. Reserpine administration in rodents has been suggested as a pharmacological model of PD based on the effects of this monoamine-depleting agent on motor activity. Here, we describe that repeated administration with a low dose (0.1 mg/kg) of reserpine in rats induces a gradual appearance of motor signs, evaluated by catalepsy behavior. Furthermore, these motor signs are accompanied by increased levels of striatal lipid peroxidation. However, treatment with reserpine failed to induce memory impairments (evaluated by novel object recognition and discriminative avoidance tasks) and alterations in hippocampal lipid peroxidation. Thus, repeated treatment with low doses of reserpine progressively induces alterations in motor function and an increase in striatal oxidative stress, indicating a possible application of this model in the study of the neuroprogressive nature of the motor signs in PD. (c) 2012 Elsevier B.V. All rights reserved.
Keywords Reserpine
Parkinson's disease
Memory
Movement disorders
Oxidative stress
Animal model
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundacao de Apoio a Pesquisa do Estado do Rio Grande do Norte (FAPERN)
Pro-reitoria de Pesquisa da Universidade Federal do Rio Grande do Norte (PROPESQ/UFRN)
Date 2012-05-16
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 231, n. 1, p. 154-163, 2012.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 154-163
Origin http://dx.doi.org/10.1016/j.bbr.2012.03.008
Access rights Closed access
Type Article
Web of Science ID WOS:000304024900019
URI http://repositorio.unifesp.br/handle/11600/34896

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