Does the neonatal clinical risk for illness severity influence pain reactivity and recovery in preterm infants?

Does the neonatal clinical risk for illness severity influence pain reactivity and recovery in preterm infants?

Author Valeri, B. O. Google Scholar
Gaspardo, C. M. Google Scholar
Martinez, F. E. Google Scholar
Linhares, M. B. M. Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: the biobehavioural pain reactivity and recovery of preterm infants in the neonatal period may reflect the capacity of the central nervous system to regulate neurobiological development.Objective: the aim of the present study was to analyse the influence of the neonatal clinical risk for illness severity on biobehavioural pain reactivity in preterm infants.Methods: Fifty-two preterm infants were allocated into two groups according to neonatal severity of illness, as measured by the Clinical Risk Index for Babies (CRIB). the low clinical risk (LCr) group included 30 neonates with CRIB scores <4, and the high clinical risk (HCr) group included 22 neonates with CRIB scores >= 4. Pain reactivity was assessed during a blood collection, which was divided into five phases (baseline, antisepsis, puncture, recovery-dressing and recovery-resting). Behavioral pain reactivity was measured using the scores, and magnitude of responses in Neonatal Facial Coding System (NFCS) and Sleep-Wake States Scale (SWS). the heart rate was continuously recorded.Results: the HCr demonstrated a higher magnitude of response on the SWS score from the baseline to the puncture phase than the LCr. Also, the HCr exhibited a higher mean heart rate and minimum heart rate than the LCr in the recovery-resting phase. in addition, the HCr exhibited a higher minimum heart rate from the baseline to the recovery-resting phase than the LCr.Conclusion: the infants exhibiting a high neonatal clinical risk showed high arousal during the puncture procedure and higher physiological reactivity in the recovery phase.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-05-01
Published in European Journal of Pain. Hoboken: Wiley-Blackwell, v. 16, n. 5, p. 727-736, 2012.
ISSN 1090-3801 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 727-736
Access rights Closed access
Type Article
Web of Science ID WOS:000306901700011

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