Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference

Show simple item record Zacarias, Marina S. [UNIFESP] Ramos, Anna C. [UNIFESP] Alves, Danielle R. [UNIFESP] Galduroz, Jose C. F. [UNIFESP] 2016-01-24T14:27:06Z 2016-01-24T14:27:06Z 2012-04-04
dc.identifier.citation Neuroscience Letters. Clare: Elsevier B.V., v. 513, n. 2, p. 129-131, 2012.
dc.identifier.issn 0304-3940
dc.description.abstract It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and projects to several forebrain structures, is known to be critically involved in the neurobiology of cocaine dependence, acetylcholine (ACh) has also been shown to play an important role in cocaine dependence via its action on this reward system. ACh is also important in the formation of hippocampal memory associated with appetitive behavior. Thus, the aim of this study was to evaluate the effect of biperiden, an ACh antagonist with high affinity for muscarinic M1 type receptors, on the acquisition of cocaine-conditioned place preference (CPP) in mice. the cocaine and biperiden were dissolved in sterile saline and were administered intraperitoneally at a dose of 10 mg/kg. the conditioning regime was 8 days long, and the cholinergic antagonist was given immediately at the end of each conditioning session. the test for CPP occurred 24 h after the last session. the results showed that animals treated with biperiden spent significantly less time in the cocaine-paired compartment than did the ones treated with saline. This finding represents a reduction in the consolidation of cocaine-induced CPP. One hypothesis that could explain this outcome focuses on the action of cholinergic antagonists on the consolidation of contextual memories. the amnesic effect of M1 antagonists on aversive tasks and on morphine CPP has been demonstrated when administered before the training or the conditioning session. the present study highlights the possibility of impairment in the acquisition of an appetitive memory, even when the cholinergic drug is administered after the conditioning session. This protocol also rejects the possibility of performance disturbance and suggests a possible pharmacological tool in the treatment of cocaine dependence. (c) 2012 Published by Elsevier Ireland Ltd. en
dc.description.sponsorship Associacao Fundo de Incentivo a Pesquisa (AFIP)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 129-131
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Neuroscience Letters
dc.rights Acesso restrito
dc.subject Acetylcholine en
dc.subject Biperiden en
dc.subject Cocaine en
dc.subject Memory consolidation en
dc.subject Conditioned place preference en
dc.title Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.identifier.doi 10.1016/j.neulet.2012.01.073
dc.description.source Web of Science
dc.identifier.wos WOS:000303090300005


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