The effect of different training programs on antioxidant status, oxidative stress, and metabolic control in type 2 diabetes

The effect of different training programs on antioxidant status, oxidative stress, and metabolic control in type 2 diabetes

Autor Oliveira, Vanessa Neves de Google Scholar
Bessa, Artur Google Scholar
Mendonca Pereira Jorge, Maria Luiza Google Scholar
Silva Oliveira, Renato Jose da Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
De Agostini, Guilherme Gularte Google Scholar
Jorge, Paulo Tannus Google Scholar
Espindola, Foued Salmen Google Scholar
Instituição Universidade Federal de Uberlândia (UFU)
Universidade Federal de São Paulo (UNIFESP)
Resumo We compared the effects of 12 weeks of 3 different exercise types on type 2 diabetic (T2DM) male and female human subjects, randomly divided into 4 groups: aerobic training (AT; n = 11), strength training (ST; n = 10), combined training (CBT; n = 10), and no training (NT; n = 12). Metabolic control, anthropometric parameters, lipid and hematological profiles, kidney and liver function markers, hormones, antioxidant enzymes, and oxidative stress markers were assessed prior to and after the training programs. At baseline, fasting blood glucose and hemoglobin A(1c) in the ST group were higher than in the NT group; after the training, we no longer observed differences in these groups, suggesting an improvement on these parameters. in the AT group, catalase and superoxide dismutase activity, nitrite concentration, levels of sulfhydryl groups, and peak rate of oxygen consumption were elevated after the training (p < 0.05). No changes were observed in antioxidant enzymes or oxidative stress markers in the ST group. the levels of sulfhydryl groups diminished in the NT group (p < 0.01) and increased in the CBT group (p < 0.05). These data demonstrate that the AT program for the T2DM subjects provided important upregulation in antioxidant enzymes and increased nitric oxide bioavailability, which may help minimize oxidative stress and the development of the chronic complications of diabetes. We propose that the beneficial effects observed in the metabolic parameters of the ST group occurred in response to the poor baseline metabolic health n this group, and not necessarily in response to the training itself.
Assunto diabetes
exercise
metabolic control
oxidative stress
aerobic training
strength training
combined training
salivary nitrite
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Número do financiamento FAPEMIG: EDT 3273/06
Data 2012-04-01
Publicado em Applied Physiology Nutrition and Metabolism-physiologie Appliquee Nutrition Et Metabolisme. Ottawa: Canadian Science Publishing, Nrc Research Press, v. 37, n. 2, p. 334-344, 2012.
ISSN 1715-5312 (Sherpa/Romeo, fator de impacto)
Editor Canadian Science Publishing, Nrc Research Press
Extensão 334-344
Fonte http://dx.doi.org/10.1139/H2012-004
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000302561100018
URI http://repositorio.unifesp.br/handle/11600/34779

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