Development and validation of a tool for identifying women with low bone mineral density and low-impact fractures: the So Paulo Osteoporosis Risk Index (SAPORI)

Development and validation of a tool for identifying women with low bone mineral density and low-impact fractures: the So Paulo Osteoporosis Risk Index (SAPORI)

Author Pinheiro, M. M. Autor UNIFESP Google Scholar
Reis Neto, Edgard Torres dos Autor UNIFESP Google Scholar
Machado, F. S. Autor UNIFESP Google Scholar
Omura, F. Autor UNIFESP Google Scholar
Szejnfeld, J. Autor UNIFESP Google Scholar
Szejnfeld, V. L. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Fundacao Inst Estudo & Pesquisa Diagnost Imagem
Inst Estudo & Pesquisa Diagnost Imagem FIDI
Abstract The performance of the So Paulo Osteoporosis Risk Index (SAPORI) was tested in 1,915 women from the original cohort, So Paulo Osteoporosis Study (SAPOS) (N = 4332). This new tool was able to identify women with low bone density (spine and hip) and low-impact fracture, with an area under the receiving operator curve (ROC) of 0.831, 0.724, and 0.689, respectively.A number of studies have demonstrated the clinical relevance of risk factors for identifying individuals at risk of fracture (Fx) and osteoporosis (OP). the SAPOS is an epidemiological study for the assessment of risk factors for Fx and low bone density in women from the community of the metropolitan area of So Paulo, Brazil. the aim of the present study was to develop and validate a tool for identifying women at higher risk for OP and low-impact Fx.A total of 4,332 pre-, peri-, and postmenopausal women were analyzed through a questionnaire addressing risk factors for OP and Fx. All of them performed bone densitometry at the lumbar spine and proximal femur (DPX NT, GE-Lunar). Following the identification of the main risk factors for OP and Fx through multivariate and logistic regression, respectively, the SAPORI was designed and subsequently validated on a second cohort of 1,915 women from the metropolitan community of So Paulo. the performance of this tool was assessed through ROC analysis.The main and significant risk factors associated with low bone density and low-impact Fx were low body weight, advanced age, Caucasian ethnicity, family history of hip Fx, current smoking, and chronic use of glucocorticosteroids. Hormonal replacement therapy and regular physical activity in the previous year played a protective role (p < 0.05). After the statistical adjustments, the SAPORI was able to identify women with low bone density (T-score a parts per thousand currency signaEuro parts per thousand a'2 standard deviations) in the femur, with 91.4% sensitivity, 52% specificity, and an area under the ROC of 0.831 (p < 0.001). At the lumbar spine, the performance was similar (81.5% sensitivity, 50% specificity, and area under ROC of 0.724; p < 0.001). Regarding the identification of low-impact Fx, the sensitivity was 71%, the specificity was 52%, and the area under the ROC was 0.689 (p < 0.001).The SAPORI is a simple, useful, fast, practice, and valid tool for identifying women at higher risk for low bone density and osteoporotic fractures.
Keywords Bone density
Clinical risk factors
Epidemiology
Fractures
Osteoporosis
Risk assessment tool
Language English
Date 2012-04-01
Published in Osteoporosis International. London: Springer London Ltd, v. 23, n. 4, p. 1371-1379, 2012.
ISSN 0937-941X (Sherpa/Romeo, impact factor)
Publisher Springer
Extent 1371-1379
Origin http://dx.doi.org/10.1007/s00198-011-1722-y
Access rights Closed access
Type Article
Web of Science ID WOS:000301790500019
URI http://repositorio.unifesp.br/handle/11600/34746

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