The Role of Pro-inflammatory and Anti-inflammatory Adipokines on Exercise-Induced Bronchospasm in Obese Adolescents Undergoing Treatment

The Role of Pro-inflammatory and Anti-inflammatory Adipokines on Exercise-Induced Bronchospasm in Obese Adolescents Undergoing Treatment

Author Silva, Patricia Leao da Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Cheik, Nadia Carla Google Scholar
Sanches, Priscila Lima Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Corgosinho, Flavia Campos Autor UNIFESP Google Scholar
Campos, Raquel Munhoz da Silveira Autor UNIFESP Google Scholar
Carnier, June Autor UNIFESP Google Scholar
Inoue, Daniela Autor UNIFESP Google Scholar
Nascimento, Claudia Maria Oller do Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Damaso, Ana Raimunda Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Uberlândia (UFU)
Abstract BACKGROUND: Recent studies have demonstrated a greater prevalence in exercise-induced bronchospasm (EIB) in obese adolescents. However, the role of pro-/anti-inflammatory adipokines and the repercussions of obesity treatment on EIB need to be explored further. Therefore, the objective of this study was to evaluate the role of pro-/anti-inflammatory adipokines on EIB in obese adolescents evaluated after long-term interdisciplinary therapy. METHODS: Thirty-five post-pubertal obese adolescents, including 20 non-EIB (body mass index [BMI] 36 +/- 5 kg/m(2)) and 15 EIB (BMI 36 +/- 5 kg/m(2)), were enrolled in this study. Body composition was measured by plethysmography, using the BOD POD body composition system, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin and leptin were analyzed. EIB and lung function were evaluated according to the American Thoracic Society criteria. Patients were recruited to a 1-year interdisciplinary intervention of weight loss, consisting of medical, nutritional, exercise, and psychological components. RESULTS: Anthropometrics and lung function variables improved significantly after the therapy in both groups. Furthermore we observed a reduction in EIB occurrence in obese adolescents after treatment. There was an increase in adiponectin levels and a reduction in leptin levels after the therapy. in addition, a low FEV1 value was a risk factor associated with EIB occurrence at baseline, and was correlated after treatment with changes in anthropometric and maximal O-2 consumption values as well as the adipokines profile. CONCLUSIONS: in the present study it was demonstrated that 1 year of interdisciplinary therapy decreased EIB frequency in obese adolescents, paralleled by an increase in lung function and improvement in pro-/anti-inflammatory adipokines.
Keywords obesity
adolescents
adipokines
bronchospasm
exercise-induced
treatment
interdisciplinary studies
Language English
Sponsor Associacao Fundo de Incentivo Pesquisa (AFIP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Centro de Excelencia Esportiva (CENESP)
Grant number FAPESP: 2008/53069-0
FAPESP: FAPESP 2006/00684-3
FAPESP: FAPESP 98/14303-3
Date 2012-04-01
Published in Respiratory Care. Irving: Daedalus Enterprises Inc, v. 57, n. 4, p. 572-582, 2012.
ISSN 0020-1324 (Sherpa/Romeo, impact factor)
Publisher Daedalus Enterprises Inc
Extent 572-582
Origin http://dx.doi.org/10.4187/respcare.01307
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000302928500010
URI http://repositorio.unifesp.br/handle/11600/34738

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