Peptides of the Constant Region of Antibodies Display Fungicidal Activity

Peptides of the Constant Region of Antibodies Display Fungicidal Activity

Author Polonelli, Luciano Google Scholar
Ciociola, Tecla Google Scholar
Magliani, Walter Google Scholar
Zanello, Pier Paolo Google Scholar
D'Adda, Tiziana Google Scholar
Galati, Serena Google Scholar
De Bernardis, Flavia Google Scholar
Arancia, Silvia Google Scholar
Gabrielli, Elena Google Scholar
Pericolini, Eva Google Scholar
Vecchiarelli, Anna Google Scholar
Arruda, Denise C. Autor UNIFESP Google Scholar
Pinto, Marcia R. Google Scholar
Travassos, Luiz Rodolpho Autor UNIFESP Google Scholar
Pertinhez, Thelma A. Google Scholar
Spisni, Alberto Google Scholar
Conti, Stefania Google Scholar
Institution Univ Parma
Ist Super Sanita
Univ Perugia
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract Synthetic peptides with sequences identical to fragments of the constant region of different classes (IgG, IgM, IgA) of antibodies (Fc-peptides) exerted a fungicidal activity in vitro against pathogenic yeasts, such as Candida albicans, Candida glabrata, Cryptococcus neoformans, and Malassezia furfur, including caspofungin and triazole resistant strains. Alanine-substituted derivatives of fungicidal Fc-peptides, tested to evaluate the critical role of each residue, displayed unaltered, increased or decreased candidacidal activity in vitro. An Fc-peptide, included in all human IgGs, displayed a therapeutic effect against experimental mucosal and systemic candidiasis in mouse models. It is intriguing to hypothesize that some Fc-peptides may influence the antifungal immune response and constitute the basis for devising new antifungal agents.
Language English
Sponsor Italian Ministry of Health
Grant number Italian Ministry of Health: 40H39
Date 2012-03-21
Published in Plos One. San Francisco: Public Library Science, v. 7, n. 3, 10 p., 2012.
ISSN 1932-6203 (Sherpa/Romeo, impact factor)
Publisher Public Library Science
Extent 10
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000303857100067

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