Beneficial effect of donepezil on obstructive sleep apnea: A double-blind, placebo-controlled clinical trial

Beneficial effect of donepezil on obstructive sleep apnea: A double-blind, placebo-controlled clinical trial

Author Sukys-Claudino, Lucia Autor UNIFESP Google Scholar
Moraes, Walter Autor UNIFESP Google Scholar
Guilleminault, Christian Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Poyares, Dalva Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Stanford Univ
Abstract Introduction/objectives: Previous publications have shown beneficial effects of cholinergic medication on obstructive sleep apnea (USA) in Alzheimer's disease (AD) patients. We hypothesized that cholinergic medication could also improve USA in non-AD patients. the present study evaluated the effects of donepezil on USA in non-AD patients.Methods: A randomized, double-blind, placebo-controlled study was conducted. the final sample consisted of 21 male patients with mild to severe USA and AHI >10 divided into two groups, a donepezil-treated group (n = 11) and a placebo-treated group (n = 10). the dosage was one tablet/day (5 mg) for the first two weeks and two tablets/day (10 mg) for the last two weeks. Polysomnography and sleepiness evaluations were performed at baseline and after one month of treatment. Groups were compared using two-way ANOVA for repeated measures with treatment-group and treatment-time as the main factors and time-treatment as an interaction effect.Results: Considering the effect of the interaction with time-treatment, there was a significant improvement in the obstructive apnea/hypopnea index, desaturation index, percentage of time with O-2 saturation <= 3% lower than baseline, lowest oxygen saturation, and the Epworth Sleepiness Scale (ESS) scores with donepezil treatment (p < 0.05). Sleep efficiency significantly decreased (p < 0.01).Conclusions: Donepezil treatment improved obstructive sleep apnea index, oxygen saturation, and sleepiness in parallel with a reduction in sleep efficiency. Our findings support the concept that cholinergic transmission may influence breathing regulation in USA patients. (C) 2011 Elsevier B.V. All rights reserved.
Keywords Obstructive sleep apnea
Donepezil
Oxygen desaturation
Cholinergic
Acetyl-cholinesterase
Polysomnography
Sleepiness
Treatment
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
AFIP
Date 2012-03-01
Published in Sleep Medicine. Amsterdam: Elsevier B.V., v. 13, n. 3, p. 290-296, 2012.
ISSN 1389-9457 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 290-296
Origin http://dx.doi.org/10.1016/j.sleep.2011.09.014
Access rights Closed access
Type Article
Web of Science ID WOS:000301695600012
URI http://repositorio.unifesp.br/handle/11600/34687

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