Beneficial effect of donepezil on obstructive sleep apnea: A double-blind, placebo-controlled clinical trial

Beneficial effect of donepezil on obstructive sleep apnea: A double-blind, placebo-controlled clinical trial

Autor Sukys-Claudino, Lucia Autor UNIFESP Google Scholar
Moraes, Walter Autor UNIFESP Google Scholar
Guilleminault, Christian Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Poyares, Dalva Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Stanford Univ
Resumo Introduction/objectives: Previous publications have shown beneficial effects of cholinergic medication on obstructive sleep apnea (USA) in Alzheimer's disease (AD) patients. We hypothesized that cholinergic medication could also improve USA in non-AD patients. the present study evaluated the effects of donepezil on USA in non-AD patients.Methods: A randomized, double-blind, placebo-controlled study was conducted. the final sample consisted of 21 male patients with mild to severe USA and AHI >10 divided into two groups, a donepezil-treated group (n = 11) and a placebo-treated group (n = 10). the dosage was one tablet/day (5 mg) for the first two weeks and two tablets/day (10 mg) for the last two weeks. Polysomnography and sleepiness evaluations were performed at baseline and after one month of treatment. Groups were compared using two-way ANOVA for repeated measures with treatment-group and treatment-time as the main factors and time-treatment as an interaction effect.Results: Considering the effect of the interaction with time-treatment, there was a significant improvement in the obstructive apnea/hypopnea index, desaturation index, percentage of time with O-2 saturation <= 3% lower than baseline, lowest oxygen saturation, and the Epworth Sleepiness Scale (ESS) scores with donepezil treatment (p < 0.05). Sleep efficiency significantly decreased (p < 0.01).Conclusions: Donepezil treatment improved obstructive sleep apnea index, oxygen saturation, and sleepiness in parallel with a reduction in sleep efficiency. Our findings support the concept that cholinergic transmission may influence breathing regulation in USA patients. (C) 2011 Elsevier B.V. All rights reserved.
Assunto Obstructive sleep apnea
Donepezil
Oxygen desaturation
Cholinergic
Acetyl-cholinesterase
Polysomnography
Sleepiness
Treatment
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
AFIP
Data 2012-03-01
Publicado em Sleep Medicine. Amsterdam: Elsevier B.V., v. 13, n. 3, p. 290-296, 2012.
ISSN 1389-9457 (Sherpa/Romeo, fator de impacto)
Editor Elsevier B.V.
Extensão 290-296
Fonte http://dx.doi.org/10.1016/j.sleep.2011.09.014
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000301695600012
URI http://repositorio.unifesp.br/handle/11600/34687

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