Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappa Bp65 signaling in adult offspring

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dc.contributor.author Pimentel, Gustavo D. [UNIFESP]
dc.contributor.author Lira, Fabio S. [UNIFESP]
dc.contributor.author Rosa, Jose C. [UNIFESP]
dc.contributor.author Oliveira, Juliana L. [UNIFESP]
dc.contributor.author Losinskas-Hachul, Ana C. [UNIFESP]
dc.contributor.author Souza, Gabriel I. H. [UNIFESP]
dc.contributor.author Carmo, Maria das Gracas T. do
dc.contributor.author Santos, Ronaldo V. T. [UNIFESP]
dc.contributor.author Mello, Marco T. de [UNIFESP]
dc.contributor.author Tufik, Sergio [UNIFESP]
dc.contributor.author Seelaender, Marilia [UNIFESP]
dc.contributor.author Oyama, Lila M. [UNIFESP]
dc.contributor.author Oller do Nascimento, Claudia M. [UNIFESP]
dc.contributor.author Watanabe, Regina H. [UNIFESP]
dc.contributor.author Ribeiro, Eliane B. [UNIFESP]
dc.contributor.author Pisani, Luciana P. [UNIFESP]
dc.date.accessioned 2016-01-24T14:26:55Z
dc.date.available 2016-01-24T14:26:55Z
dc.date.issued 2012-03-01
dc.identifier http://dx.doi.org/10.1016/j.jnutbio.2010.12.003
dc.identifier.citation Journal of Nutritional Biochemistry. New York: Elsevier B.V., v. 23, n. 3, p. 265-271, 2012.
dc.identifier.issn 0955-2863
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34681
dc.description.abstract We examined whether feeding pregnant and lactating rats with hydrogenated vegetable fats rich in trans fatty acids led to an increase in serum endotoxin levels and inflammation and to impaired satiety-sensing pathways in the hypothalamus of 90-day-old offspring. Pregnant and lactating Wistar rats were fed either a standard chow (Control) or one enriched with hydrogenated vegetable fat (Trans). Upon weaning, the male offspring were divided in two groups: Control-Control (CC), mothers and offspring fed the control diet; and Trans-Control (TC), mothers fed the trans diet, and offspring fed the control diet the offspring's food intake and body weight were quantified weekly and the offspring were killed on the 90th day of life by decapitation. the blood and hypothalamus were collected from the offspring. Food intake and body weight were higher in the TC rats than in the CC rats. TC rats had increased serum endotoxin levels and increased hypothalamic cytokines, IL-6, TNF-alpha and IL1-beta, concentrations (P<.05). TLR4, NF kappa Bp65 and MyD88 were higher (P <.05) in the TC rats than in the CC rats. AdipoR1 was lower in the TC rats than in the CC rats. Thus, the present study shows that the mothers' hydrogenated vegetable fat intake during pregnancy and lactation led to hypothalamic inflammation and impaired satiety-sensing, which promotes deleterious metabolic consequences such as obesity, even after the withdrawal of the causal factor. in other words, the effect remains after the consumption of the standard chow by offspring. (C) 2012 Elsevier Inc. All rights reserved. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 265-271
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Journal of Nutritional Biochemistry
dc.rights Acesso restrito
dc.subject Trans fatty acids en
dc.subject Hypothalamic inflammation en
dc.subject Cytokines en
dc.subject Adiponectin receptor en
dc.subject Fetal programming en
dc.title Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappa Bp65 signaling in adult offspring en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.description.affiliation Universidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliation Univ Fed Rio de Janeiro, Lab Bioquim Nutr, Inst Nutr Josue de Castro, Rio de Janeiro, RJ, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Inst Ciencias Biomed, Dept Biol Celular & Desenvolvimento, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Ciencias Saude, Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Fisiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biociencias, Santos, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Psicobiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Inst Ciencias Biomed, Dept Biol Celular & Desenvolvimento, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Ciencias Saude, Santos, SP, Brazil
dc.identifier.doi 10.1016/j.jnutbio.2010.12.003
dc.description.source Web of Science
dc.identifier.wos WOS:000300914200008



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