Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappa Bp65 signaling in adult offspring

Intake of trans fatty acids during gestation and lactation leads to hypothalamic inflammation via TLR4/NF kappa Bp65 signaling in adult offspring

Author Pimentel, Gustavo D. Autor UNIFESP Google Scholar
Lira, Fabio S. Autor UNIFESP Google Scholar
Rosa, Jose C. Autor UNIFESP Google Scholar
Oliveira, Juliana L. Autor UNIFESP Google Scholar
Losinskas-Hachul, Ana C. Autor UNIFESP Google Scholar
Souza, Gabriel I. H. Autor UNIFESP Google Scholar
Carmo, Maria das Gracas T. do Google Scholar
Santos, Ronaldo V. T. Autor UNIFESP Google Scholar
Mello, Marco T. de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Seelaender, Marilia Autor UNIFESP Google Scholar
Oyama, Lila M. Autor UNIFESP Google Scholar
Oller do Nascimento, Claudia M. Autor UNIFESP Google Scholar
Watanabe, Regina H. Autor UNIFESP Google Scholar
Ribeiro, Eliane B. Autor UNIFESP Google Scholar
Pisani, Luciana P. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Rio de Janeiro (UFRJ)
Abstract We examined whether feeding pregnant and lactating rats with hydrogenated vegetable fats rich in trans fatty acids led to an increase in serum endotoxin levels and inflammation and to impaired satiety-sensing pathways in the hypothalamus of 90-day-old offspring. Pregnant and lactating Wistar rats were fed either a standard chow (Control) or one enriched with hydrogenated vegetable fat (Trans). Upon weaning, the male offspring were divided in two groups: Control-Control (CC), mothers and offspring fed the control diet; and Trans-Control (TC), mothers fed the trans diet, and offspring fed the control diet the offspring's food intake and body weight were quantified weekly and the offspring were killed on the 90th day of life by decapitation. the blood and hypothalamus were collected from the offspring. Food intake and body weight were higher in the TC rats than in the CC rats. TC rats had increased serum endotoxin levels and increased hypothalamic cytokines, IL-6, TNF-alpha and IL1-beta, concentrations (P<.05). TLR4, NF kappa Bp65 and MyD88 were higher (P <.05) in the TC rats than in the CC rats. AdipoR1 was lower in the TC rats than in the CC rats. Thus, the present study shows that the mothers' hydrogenated vegetable fat intake during pregnancy and lactation led to hypothalamic inflammation and impaired satiety-sensing, which promotes deleterious metabolic consequences such as obesity, even after the withdrawal of the causal factor. in other words, the effect remains after the consumption of the standard chow by offspring. (C) 2012 Elsevier Inc. All rights reserved.
Keywords Trans fatty acids
Hypothalamic inflammation
Cytokines
Adiponectin receptor
Fetal programming
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2012-03-01
Published in Journal of Nutritional Biochemistry. New York: Elsevier B.V., v. 23, n. 3, p. 265-271, 2012.
ISSN 0955-2863 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 265-271
Origin http://dx.doi.org/10.1016/j.jnutbio.2010.12.003
Access rights Closed access
Type Article
Web of Science ID WOS:000300914200008
URI http://repositorio.unifesp.br/handle/11600/34681

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account