Annexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in rats

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dc.contributor.author Araujo, Leandro Pires [UNIFESP]
dc.contributor.author Truzzi, Renata Ramos
dc.contributor.author Florido Mendes, Gloria Elisa
dc.contributor.author Mendes Luz, Marcus Alexandre
dc.contributor.author Burdmann, Emmanuel A.
dc.contributor.author Oliani, Sonia Maria [UNIFESP]
dc.date.accessioned 2016-01-24T14:26:52Z
dc.date.available 2016-01-24T14:26:52Z
dc.date.issued 2012-03-01
dc.identifier http://dx.doi.org/10.1007/s00011-011-0400-z
dc.identifier.citation Inflammation Research. Basel: Springer Basel Ag, v. 61, n. 3, p. 189-196, 2012.
dc.identifier.issn 1023-3830
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34657
dc.description.abstract Cyclosporine (CsA) remains an important immunosuppressant for transplantation and for treatment of autoimmune diseases. the most troublesome side effect of CsA is renal injury. Acute CsA-induced nephrotoxicity is characterized by reduced renal blood flow (RBF) and glomerular filtration rate (GFR) due to afferent arteriole vasoconstriction. Annexin A1 (ANXA1) is a potent anti-inflammatory protein with protective effect in renal ischemia/reperfusion injury. Here we study the effects of ANXA1 treatment in an experimental model of acute CsA nephrotoxicity.Salt-depleted rats were randomized to treatment with VH (vehicles 1 mL/kg body weight/day), ANXA1 (Ac2-26 peptide 1 mg/kg body weight/day intraperitoneally), CsA (20 mg/kg body weight/day subcutaneously) and CsA + ANXA1 (combination) for seven days. We compared renal function and hemodynamics, renal histopathology, renal tissue macrophage infiltration and renal ANXA1 expression between the four groups.CsA significantly impaired GFR and RBF, caused tubular dilation and macrophage infiltration and increased ANXA1 renal tissue expression. Treatment with ANXA1 attenuated CSA-induced hemodynamic changes, tubular injury and macrophage infiltration.ANXA1 treatment attenuated renal hemodynamic injury and inflammation in an acute CsA nephrotoxicity model. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 189-196
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartof Inflammation Research
dc.rights Acesso restrito
dc.subject Acute renal injury en
dc.subject Annexin A1 en
dc.subject Cyclosporine nephrotoxicity en
dc.subject Immunosuppression en
dc.subject Inflammation en
dc.title Annexin A1 protein attenuates cyclosporine-induced renal hemodynamics changes and macrophage infiltration in rats en
dc.type Artigo
dc.rights.license http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.contributor.institution São Paulo State Univ UNESP
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Sao Jose do Rio Preto Med Sch
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation São Paulo State Univ UNESP, Inst Biociencias Letras & Ciencias Exatas IBILCE, Dept Biol, BR-15054000 São Paulo, Brazil
dc.description.affiliation Fed Univ São Paulo UNIFESP, Postgrad Program Morphol, São Paulo, Brazil
dc.description.affiliation Sao Jose do Rio Preto Med Sch, Div Nephrol, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Postgrad Program Morphol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2008/01,048-9
dc.description.sponsorshipID CNPq: 306,074/2007-9
dc.description.sponsorshipID CNPq: 307,371/2006-9
dc.identifier.doi 10.1007/s00011-011-0400-z
dc.description.source Web of Science
dc.identifier.wos WOS:000300292100002



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