Strength Training with Blood Flow Restriction Diminishes Myostatin Gene Expression

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dc.contributor.author Laurentino, Gilberto Candido
dc.contributor.author Ugrinowitsch, Carlos
dc.contributor.author Roschel, Hamilton
dc.contributor.author Aoki, Marcelo Saldanha
dc.contributor.author Soares, Antonio Garcia
dc.contributor.author Neves, Manoel
dc.contributor.author Aihara, Andre Yui [UNIFESP]
dc.contributor.author Fernandes, Artur da Rocha Correa [UNIFESP]
dc.contributor.author Tricoli, Valmor
dc.date.accessioned 2016-01-24T14:17:57Z
dc.date.available 2016-01-24T14:17:57Z
dc.date.issued 2012-03-01
dc.identifier http://dx.doi.org/10.1249/MSS.0b013e318233b4bc
dc.identifier.citation Medicine and Science in Sports and Exercise. Philadelphia: Lippincott Williams & Wilkins, v. 44, n. 3, p. 406-412, 2012.
dc.identifier.issn 0195-9131
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34646
dc.description.abstract LAURENTINO, G. C., C. UGRINOWITSCH, H. ROSCHEL, M. S. AOKI, A. G. SOARES, M. NEVES JR, A. Y. AIHARA, A. DA ROCHA CORREA FERNANDES, and V. TRICOLI. Strength Training with Blood Flow Restriction Diminishes Myostatin Gene Expression. Med. Sci. Sports Exerc., Vol. 44, No. 3, pp. 406-412, 2012. Purpose: the aim of the study was to determine whether the similar muscle strength and hypertrophy responses observed after either low-intensity resistance exercise associated with moderate blood flow restriction or high-intensity resistance exercise are associated with similar changes in messenger RNA (mRNA) expression of selected genes involved in myostatin (MSTN) signaling. Methods: Twenty-nine physically active male subjects were divided into three groups: low-intensity (20% one-repetition maximum (1RM)) resistance training (LI) (n = 10), low-intensity resistance exercise associated with moderate blood flow restriction (LIR) (n = 10), and high-intensity (80% 1RM) resistance exercise (HI) (n = 9). All of the groups underwent an 8-wk training program. Maximal dynamic knee extension strength (1RM), quadriceps cross-sectional area (CSA), MSTN, follistatin-like related genes (follistatin (FLST), follistatin-like 3 (FLST-3)), activin IIb, growth and differentiation factor-associated serum protein 1 (GASP-1), and MAD-related protein (SMAD-7) mRNA gene expression were assessed before and after training. Results: Knee extension 1RM significantly increased in all groups (LI = 20.7%, LIR = 40.1%, and HI = 36.2%). CSA increased in both the LIR and HI groups (6.3% and 6.1%, respectively). MSTN mRNA expression decreased in the LIR and HI groups (45% and 41%, respectively). There were no significant changes in activin IIb (P > 0.05). FLST and FLST-3 mRNA expression increased in all groups from pre- to posttest (P < 0.001). FLST-3 expression was significantly greater in the HI when compared with the LIR and LI groups at posttest (P = 0.024 and P = 0.018, respectively). GASP-1 and SMAD-7 gene expression significantly increased in both the LIR and HI groups. Conclusions: We concluded that LIR was able to induce gains in 1RM and quadriceps CSA similar to those observed after traditional HI. These responses may be related to the concomitant decrease in MSTN and increase in FLST isoforms, GASP-1, and SMAD-7 mRNA gene expression. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 406-412
dc.language.iso eng
dc.publisher Lippincott Williams & Wilkins
dc.relation.ispartof Medicine and Science in Sports and Exercise
dc.rights Acesso aberto
dc.subject RESISTANCE TRAINING en
dc.subject SKELETAL MUSCLE HYPERTROPHY en
dc.subject MUSCLE BIOPSY en
dc.subject VASCULAR OCCLUSION en
dc.subject HYPOXIA en
dc.title Strength Training with Blood Flow Restriction Diminishes Myostatin Gene Expression en
dc.type Artigo
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ São Paulo, Sch Phys Educ & Sport, Dept Sport, BR-05508030 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Med, Div Rheumatol, BR-05508030 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Arts Sci & Humanities, BR-05508030 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Inst Biomed Sci, BR-05508030 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Radiol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Radiol, São Paulo, Brazil
dc.description.sponsorshipID FAPESP: 2009/09820-5
dc.description.sponsorshipID FAPESP: 2010/51428-2
dc.description.sponsorshipID CNPq: 470207/2008-6
dc.description.sponsorshipID CNPq: 303162/2008-2
dc.identifier.doi 10.1249/MSS.0b013e318233b4bc
dc.description.source Web of Science
dc.identifier.wos WOS:000300639500006



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