Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy

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dc.contributor.author Almeida, S. S. [UNIFESP]
dc.contributor.author Naffah-Mazzacoratti, Maria da Graca [UNIFESP]
dc.contributor.author Guimarães, Paola Bianchi [UNIFESP]
dc.contributor.author Wasinski, F. [UNIFESP]
dc.contributor.author Pereira, F. E. G. [UNIFESP]
dc.contributor.author Canzian, Mauro [UNIFESP]
dc.contributor.author Centeno, Ricardo Silva [UNIFESP]
dc.contributor.author Carrete Junior, Henrique [UNIFESP]
dc.contributor.author Yacubian, Elza Márcia Targas [UNIFESP]
dc.contributor.author Carmona, Adriana Karaoglanovic [UNIFESP]
dc.contributor.author Vieira, Renata de Freitas Fisher [UNIFESP]
dc.contributor.author Nakaie, Clovis Ryuichi [UNIFESP]
dc.contributor.author Sabatini, R. A. [UNIFESP]
dc.contributor.author Perosa, S. R. [UNIFESP]
dc.contributor.author Bacurau, Reury Frank Pereira
dc.contributor.author Gouveia, Telma Luciana Furtado [UNIFESP]
dc.contributor.author Gallo, Gloria [UNIFESP]
dc.contributor.author Wuertele, M. [UNIFESP]
dc.contributor.author Cavalheiro, Esper Abrão [UNIFESP]
dc.contributor.author Silva, J. A.
dc.contributor.author Pesquero, João Bosco [UNIFESP]
dc.contributor.author Araujo, R. C. [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:56Z
dc.date.available 2016-01-24T14:17:56Z
dc.date.issued 2012-03-01
dc.identifier http://dx.doi.org/10.1038/tp.2012.21
dc.identifier.citation Translational Psychiatry. New York: Nature Publishing Group, v. 2, 5 p., 2012.
dc.identifier.issn 2158-3188
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34639
dc.description.abstract We find that a common mutation that increases angiotensin I-converting enzyme activity occurs with higher frequency in male patients suffering from refractory temporal lobe epilepsy. However, in their brains, the activity of the enzyme is downregulated. As an explanation, we surprisingly find that carbamazepine, commonly used to treat epilepsy, is an inhibitor of the enzyme, thus providing a direct link between epilepsy and the renin-angiotensin and kallikrein-kinin systems. Translational Psychiatry (2012) 2, e93; doi:10.1038/tp.2012.21; published online 13 March 2012 en
dc.description.sponsorship INNT
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 5
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof Translational Psychiatry
dc.rights Acesso aberto
dc.subject angiotensin I-converting enzyme en
dc.subject carbamazepine en
dc.subject epilepsy en
dc.subject TLE en
dc.title Carbamazepine inhibits angiotensin I-converting enzyme, linking it to the pathogenesis of temporal lobe epilepsy en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Nove de Julho Univ UNINOVE
dc.description.affiliation Universidade Federal de São Paulo, Dept Biophys, BR-04023032 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, BR-04023032 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Pathol, BR-04023032 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023032 São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Sch Arts Sci & Humanities, São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Dept Sci & Technol, BR-04023032 São Paulo, Brazil
dc.description.affiliation Nove de Julho Univ UNINOVE, Dept Rehabil Sci, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Biophys, BR-04023032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, BR-04023032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Pathol, BR-04023032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Neurol & Neurosurg, BR-04023032 São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Sci & Technol, BR-04023032 São Paulo, Brazil
dc.identifier.file WOS000315990800009.pdf
dc.identifier.doi 10.1038/tp.2012.21
dc.description.source Web of Science
dc.identifier.wos WOS:000315990800009



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