Turner syndrome and metabolic derangements: Another example of fetal programming

Turner syndrome and metabolic derangements: Another example of fetal programming

Author Baldin, Alexandre Duarte Google Scholar
Siviero-Miachon, Adriana Aparecida Autor UNIFESP Google Scholar
Fabbri, Tatiana Autor UNIFESP Google Scholar
Valente de Lemos-Marini, Sofia Helena Google Scholar
Spinola-Castro, Angela Maria Autor UNIFESP Google Scholar
Matias Baptista, Maria Tereza Google Scholar
Rodrigues D'Souza-Li, Lilia Freire Google Scholar
Morcillo, Andre Moreno Google Scholar
Maciel-Guerra, Andrea Trevas Google Scholar
Guerra-Junior, Gil Google Scholar
Institution Universidade Estadual de Campinas (UNICAMP)
Universidade Federal de São Paulo (UNIFESP)
Abstract Background and aim: Turner syndrome (TS) patients have an increased risk of weight gain and metabolic syndrome. To date, it is unknown what factors are involved in this metabolic process, even though it is recognized that TS patients are frequently born small-for-gestational age. the aim of this study was to evaluate the correlation between lipid and glucose profiles with being overweight and birth weight and length in TS patients.Study design: This was a cross-sectional study.Subjects and outcome measures: Serum glucose, insulin (HOMA-IR), total cholesterol, and triglycerides were measured in 64 patients with TS. Data regarding birth weight and length and current body mass index (BMI) were also evaluated.Results: Total cholesterol showed a significant negative correlation with birth weight and a positive correlation with BMI; triglycerides showed significant negative correlation with birth weight and length and a positive correlation with BMI; and HOMA-IR showed a significant negative correlation with birth weight and length. Low birth weight and a high BMI were predictive for 28% of total cholesterol and triglycerides; and low birth weight for 22% of HOMA-IR.Conclusions: Lipid profile was correlated with a high current BMI and low birth weight and length in TS patients and glucose profile only with low birth weight. Thus far, growth retardation may play a role in metabolic derangements in this group of patients, being considered another example of fetal programming. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Keywords Turner syndrome
Fetal programming
Birth weight
Length weight
Body mass index
Language English
Date 2012-02-01
Published in Early Human Development. Clare: Elsevier B.V., v. 88, n. 2, p. 99-102, 2012.
ISSN 0378-3782 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 99-102
Origin http://dx.doi.org/10.1016/j.earlhumdev.2011.07.014
Access rights Closed access
Type Article
Web of Science ID WOS:000301474900010
URI http://repositorio.unifesp.br/handle/11600/34580

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