Obese adolescents with eating disorders: Analysis of metabolic and inflammatory states

Obese adolescents with eating disorders: Analysis of metabolic and inflammatory states

Author Carnier, June Autor UNIFESP Google Scholar
Sanches, Priscila de Lima Autor UNIFESP Google Scholar
Silva, Patricia Leao da Autor UNIFESP Google Scholar
Piano, Aline de Autor UNIFESP Google Scholar
Tock, Lian Autor UNIFESP Google Scholar
Campos, Raquel M. S. Autor UNIFESP Google Scholar
Corgosinho, Flavia C. Autor UNIFESP Google Scholar
Correa, Fabiola Alvise Autor UNIFESP Google Scholar
Masquio, Deborah Autor UNIFESP Google Scholar
Oller do Nascimento, Claudia Maria Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Ernandes, Regina H. Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Damaso, Ana R. Google Scholar
Institution Posgrad Program Nutr
Dept Physiol
Assoc Found Incent Res
Dept Psychobiol
Dept Biosci
Posgrad Program Interdisciplinary Hlth Sci
Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: the purpose of the present investigation was to compare the effect of interdisciplinary therapy on the physical and metabolic profiles, including body composition, insulin resistance and sensitivity as well as adiponectin and leptin concentrations, of obese adolescents with and without eating disorder symptoms.Methods: A total of 83 obese adolescents (28 with and 55 without eating disorder symptoms) were enrolled for 1 year of interdisciplinary weight-loss therapy (clinical, nutritional, exercise, physiotherapy and psychological). Bulimic and binge eating symptoms were measured by the Bulimic Investigatory Test, Edinburgh. and the Binge Eating Scale, respectively. Leptin and adiponectin concentrations were measured with enzyme-linked immunosorbent assay kits. Visceral and subcutaneous fat were assessed by ultrasonography.Results: Both groups demonstrated improved body mass, body mass index, body fat (%), lean mass, visceral fat, subcutaneous fat, homeostasis model assessment insulin-resistance index (HOMA-IR), quantitative insulin sensitivity check index, total cholesterol, LDL-cholesterol, VLDL, triglycerides, adiponectin and leptin concentrations after therapy. We found a positive correlation between leptin concentrations and subcutaneous fat in the control group and a negative correlation between adiponectin concentrations and HOMA-IR and fat mass (%). the prevalence of obese adolescents with eating disorders was reduced by 89% after 1 year of interdisciplinary therapy.Conclusion: the eating disorder symptoms did not impair the metabolic state during weight loss therapy of obese adolescents. Additionally, long-term interdisciplinary therapy was effective in reducing the chances of developing several co-morbidities in both groups. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Obesity
Interdisciplinary therapy
Leptin
Adiponectin
Eating disorders
Language English
Sponsor AFIP
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
CEMSA
UNIFESP
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 9814302-3
FAPESP: 2006/00684-3
FAPESP: 2008/53069-0
FAPESP: 2011/50356-0
Date 2012-01-18
Published in Physiology & Behavior. Oxford: Pergamon-Elsevier B.V., v. 105, n. 2, p. 175-180, 2012.
ISSN 0031-9384 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 175-180
Origin http://dx.doi.org/10.1016/j.physbeh.2011.08.014
Access rights Closed access
Type Article
Web of Science ID WOS:000300459800004
URI http://repositorio.unifesp.br/handle/11600/34532

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