Cholecalciferol Supplementation in Chronic Kidney Disease: Restoration of Vitamin D Status and Impact on Parathyroid Hormone

Cholecalciferol Supplementation in Chronic Kidney Disease: Restoration of Vitamin D Status and Impact on Parathyroid Hormone

Author Garcia-Lopes, Miriam G. Autor UNIFESP Google Scholar
Pillar, Roberta Google Scholar
Kamimura, Maria Ayako Autor UNIFESP Google Scholar
Rocha, Lillian A. Google Scholar
Canziani, Maria Eugenia F. Google Scholar
Carvalho, Aluizio B. Google Scholar
Cuppari, Lilian Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background/Aims: Hypovitaminosis D is highly prevalent among patients with chronic kidney disease (CKD) and has been associated with poor outcome. We aimed to test the effect of a protocol of cholecalciferol supplementation on the restoration of vitamin D status and on parathyroid hormone (PTH) levels in patients with CKD. Methods: This was a prospective interventional study of 6 months. Forty-five CKD patients (stages 3 and 4) with 25-hydroxyvitamin D deficiency [25(OH)D <15 ng/ml] were included. Patients received a weekly dose of 50,000 IU of cholecalciferol during 3 months, and 50,000 IU/month thereafter for those who had achieved 25(OH)D >= 30 ng/ml. Results: At 3 months, 78% of the patients restored their vitamin D status. At 6 months, only 43% of those patients maintained adequate vitamin D status. PTH decreased at 3 months (p = 0.02) but returned to baseline levels after 6 months. Fibroblast growth factor 23 increased at 3 months (p = 0.001) and returned to initial levels at 6 months. No changes were found in serum 1,25(OH)(2)D, ionized calcium and phosphorus. Conclusions: A weekly dose of 50,000 IU of cholecalciferol for 3 months restored the vitamin D status of most patients and led to a reduction in PTH. the monthly dose of 50,000 IU appears not to be sufficient to maintain the levels of 25(OH)D. Copyright (C) 2012 S. Karger AG, Basel
Keywords Adiposity
Cholecalciferol
Chronic kidney disease
Parathyroid hormone
Vitamin D
Language English
Sponsor São Paulo Foundation for Research Support
Oswaldo Ramos Foundation
Grant number São Paulo Foundation for Research Support: FAPESP 2006/03811-6
São Paulo Foundation for Research Support: FAPESP 2006/55414-0
Date 2012-01-01
Published in Annals of Nutrition and Metabolism. Basel: Karger, v. 61, n. 1, p. 74-82, 2012.
ISSN 0250-6807 (Sherpa/Romeo, impact factor)
Publisher Karger
Extent 74-82
Origin http://dx.doi.org/10.1159/000339618
Access rights Closed access
Type Article
Web of Science ID WOS:000307689900012
URI http://repositorio.unifesp.br/handle/11600/34500

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