Human papillomavirus infection in Brazilian women with normal cervical cytology

Human papillomavirus infection in Brazilian women with normal cervical cytology

Author Miranda, Priscila Mayrink Autor UNIFESP Google Scholar
Pitol, Bruna Caroline Vieira Google Scholar
Moran, Mariana Soares Google Scholar
Silva, Nayara Nascimento Toledo Google Scholar
Felix, Priscila Mueller Google Scholar
Lima-Filho, Jose Luis Google Scholar
Carneiro, Claudia Martins Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Carvalho, Rodrigo Franco Google Scholar
Lima, Angelica Alves Google Scholar
Beçak, Willy Google Scholar
Stocco, Rita de Cassia Autor UNIFESP Google Scholar
Institution Inst Butantan
Univ Fed Ouro Preto
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Pernambuco (UFPE)
Univ Fed Integracao Latinoamer
Abstract We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and prophylaxis. Cervical samples of 399 women, received for routine evaluation in the Health Department of Ouro Preto, MG, Brazil, were subjected to HPV-DNA testing by PCR with MY09/11 primers. HPV-positive specimens were typed by RFLP. A structured epidemiological questionnaire was administered to each woman. HPV prevalence among these cytologically normal women was 11%. Twelve viral types were detected, the most common being HPV-16, -6, -61, -83, and -66. HPV was more prevalent in younger women; high-risk viral types were detected in 61% of the infected women and 27% of the infected women had multiple HPV infections. Significant associations of HPV infection were found with age, literacy, residence, marital status, lifetime number of sexual partners, and parity. We detected a great diversity of HPV types in women with normal cytology. This kind of information about local populations is useful for HPV prevention and vaccination strategies.
Keywords HPV
Human papillomavirus
Cervical cancer screening
Normal cytology
Epidemiology
Risk factors
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
FACEPE (PRONEX)
Date 2012-01-01
Published in Genetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 11, n. 2, p. 1752-1761, 2012.
ISSN 1676-5680 (Sherpa/Romeo, impact factor)
Publisher Funpec-editora
Extent 1752-1761
Origin http://dx.doi.org/10.4238/2012.June.29.8
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000308633900009
URI http://repositorio.unifesp.br/handle/11600/34406

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