Electroacupuncture and Moxibustion Decrease Renal Sympathetic Nerve Activity and Retard Progression of Renal Disease in Rats

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dc.contributor.author Paterno, Josne Carla [UNIFESP]
dc.contributor.author Bergamaschi, Cassia Toledo [UNIFESP]
dc.contributor.author Campos, Ruy Ribeiro [UNIFESP]
dc.contributor.author Higa, Elisa Mieko Suemitsu [UNIFESP]
dc.contributor.author Soares, Maria Fernanda Sanches [UNIFESP]
dc.contributor.author Schor, Nestor [UNIFESP]
dc.contributor.author Freire, Anaflavia de Oliveira [UNIFESP]
dc.contributor.author Teixeira, Vicente de Paulo Castro [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:38Z
dc.date.available 2016-01-24T14:17:38Z
dc.date.issued 2012-01-01
dc.identifier http://dx.doi.org/10.1159/000336095
dc.identifier.citation Kidney & Blood Pressure Research. Basel: Karger, v. 35, n. 5, p. 355-364, 2012.
dc.identifier.issn 1420-4096
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34383
dc.description.abstract Background/Aim: Chronic kidney disease (CKD) is an increasing major public health problem worldwide. the sympathetic nervous system and nitric oxide play an important role in the pathogenesis of CKD. Traditional Chinese medicine has accumulated thousands of years of therapeutic experiences. Electroacupuncture (EA) and moxibustion (MO) are two such therapeutic strategies. the aim of this study was to investigate the renal and hemodynamic effects of EA-MO in an experimental model of a CKD. Methods: Male Wistar rats submitted to 5/6th nephrectomy (5/6 NX) were studied for 8 weeks. There were four groups: (1) control, normal rats; (2) NX, 5/6 NX only; (3) NX-AS, 5/6 NX and EA-MO session using sham points, and (4) NX-AM, 5/6 NX and EA-MO session using real acupoints. Biochemical and blood pressure studies, renal sympathetic nerve activity measurements, nitric oxide levels and the histopathological indices were assessed. Results:The EA- and MO-treated group presented significant improvement in all measured functional and histopathological parameters. Conclusion: These findings suggest that EA-MO had beneficial effects on CKD. This effect was probably achieved by the modulation of the renal sympathetic nerve activity and nitric oxide levels, leading to decreased blood pressure, which is associated with less proteinuria. Copyright (c) 2012 S. Karger AG, Basel en
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent 355-364
dc.language.iso eng
dc.publisher Karger
dc.relation.ispartof Kidney & Blood Pressure Research
dc.rights Acesso aberto
dc.subject Chronic kidney disease en
dc.subject Hypertension en
dc.subject Nitric oxide en
dc.subject Renal sympathetic nerve activity en
dc.subject Electroacupuncture en
dc.subject Moxibustion en
dc.title Electroacupuncture and Moxibustion Decrease Renal Sympathetic Nerve Activity and Retard Progression of Renal Disease in Rats en
dc.type Artigo
dc.rights.license http://www.karger.com/Services/RightsPermissions
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Physiol, Cardiovasc Physiol Div, São Paulo, Brazil
dc.description.affiliation Fed Univ São Paulo UNIFESP, Dept Pathol, São Paulo, Brazil
dc.description.affiliation Fed Univ São Paulo UNIFESP, Chinese Med & Acupuncture Div, Dept Orthoped & Traumatol, São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Med, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Physiol, Cardiovasc Physiol Div, São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifesp Fed Univ São Paulo UNIFESP, Chinese Med & Acupuncture Div, Dept Orthoped & Traumatol, São Paulo, Brazil
dc.identifier.file WOS000305594600008.pdf
dc.identifier.doi 10.1159/000336095
dc.description.source Web of Science
dc.identifier.wos WOS:000305594600008



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