Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy

Cancer/Testis Antigen MAGE-C1/CT7: New Target for Multiple Myeloma Therapy

Author Carvalho, Fabricio de Autor UNIFESP Google Scholar
Vettore, Andre L. Autor UNIFESP Google Scholar
Colleoni, Gisele W. B. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Cancer/Testis Antigens (CTAs) are a promising class of tumor antigens that have a limited expression in somatic tissues (testis, ovary, fetal, and placental cells). Aberrant expression of CTAs in cancer cells may lead to abnormal chromosome segregation and aneuploidy. CTAs are regulated by epigenetic mechanisms (DNA methylation and acetylation of histones) and are attractive targets for immunotherapy in cancer because the gonads are immune privileged organs and anti-CTA immune response can be tumor-specific. Multiple myeloma (MM) is an incurable hematological malignancy, and several CTAs have been detected in many MM cell lines and patients. Among CTAs expressed in MM we must highlight the MAGE-C1/CT7 located on the X chromosome and expressed specificity in the malignant plasma cells. MAGE-C1/CT7 seems to be related to disease progression and functional studies suggests that this CTA might play a role in cell cycle and mainly in survival of malignant plasma cells, protecting myeloma cells against spontaneous as well as drug-induced apoptosis.
Language English
Date 2012-01-01
Published in Clinical & Developmental Immunology. New York: Hindawi Publishing Corporation, 7 p., 2012.
ISSN 1740-2522 (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 7
Origin http://dx.doi.org/10.1155/2012/257695
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000302578400001
URI http://repositorio.unifesp.br/handle/11600/34367

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