Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status

Renewed Avenues through Exercise Muscle Contractility and Inflammatory Status

Author Zanchi, Nelo Eidy Google Scholar
Almeida, Felipe Natali Google Scholar
Lira, Fábio Santos de Autor UNIFESP Google Scholar
Rosa Neto, José Cesar Autor UNIFESP Google Scholar
Nicastro, Humberto Google Scholar
Luz, Claudia Ribeiro da Google Scholar
Siqueira Filho, Mario Alves de Google Scholar
Felitti, Vitor Google Scholar
Vainzof, Mariz Google Scholar
Seelaender, Marilia Google Scholar
Poortmans, Jacques R. Google Scholar
Lancha, Antonio Herbert Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Univ Libre Brussels
Abstract Physical inactivity leads to the accumulation of visceral fat and, consequently, to the activation of a network of inflammatory pathways which may promote development of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. These conditions belong to the diseasome of physical inactivity. in contrast, the protective effect of regular exercise against diseases associated with chronic inflammation may to some extent be ascribed to an anti-inflammatory effect. the so called acute exercise threshold, the complex mixture of several variables involved in exercise, such as type, volume, frequency, and intensity range is capable of inducing positive physiological adaptations and has been specifically addressed in the recent literature. the major concern is related to the level of the threshold: exercise training shifts from a therapeutic adaptive intervention to one with potential pathological consequences. Nonetheless, if the mechanical stimulus is too weak to disrupt cellular homeostasis, training adaptations will not occur. Answering these questions could present practical applications, especially during inflammatory diseases associated with detrimental muscle effects and could theoretically constitute a new therapeutic approach to treat/improve an inflammatory state. This paper aims to describe specific data from the literature regarding the effects of exercise on inflammatory diseases in order to promote a more sophisticated perspective on the anti-inflammatory effects of exercise.
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 08/51090-1
FAPESP: 10/07062-3
Date 2012-01-01
Published in Scientific World Journal. New York: Hindawi Publishing Corporation, 7 p., 2012.
ISSN 1537-744X (Sherpa/Romeo, impact factor)
Publisher Hindawi Publishing Corporation
Extent 7
Access rights Open access Open Access
Type Review
Web of Science ID WOS:000306811000001

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