Combining dose and injection volume for good performance of a specific radiopharmaceutical for sentinel node detection

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dc.contributor.author Fernandez Nunez, Eutimio Gustavo
dc.contributor.author Oliveira, Érica Aparecida de
dc.contributor.author Silva, Natanael Gomes da
dc.contributor.author Oliveira Filho, Renato Santos de [UNIFESP]
dc.date.accessioned 2016-01-24T14:17:35Z
dc.date.available 2016-01-24T14:17:35Z
dc.date.issued 2012-01-01
dc.identifier http://dx.doi.org/10.1016/j.nucmedbio.2011.07.004
dc.identifier.citation Nuclear Medicine and Biology. New York: Elsevier B.V., v. 39, n. 1, p. 145-153, 2012.
dc.identifier.issn 0969-8051
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34341
dc.description.abstract Introduction: the aim of this work was to quantify the effects of injection volume at different technetium-99m specific radiotracer doses on its lymphatic movement in animal model.Procedures: Effects of injection volume (50, 100 mu l) at different doses (0.05, 0.135, 0.22 nmol) on popliteal node (PN) detection were studied in rats. the radiotracer under study was (99m)Technetium-cysteine-mannose-dextran conjugate (30 kDa).Results: At 0.05 nmol dose, higher PN uptake was observed at 50 mu l injection volume (2.6 fold increase). Conversely, at 0.135 nmol dose, an increase of radiotracer retention in PN was achieved at 100 mu l volume, 78% higher than 50 mu l. However, at 0.22 nmol close, the injection volume changes did not influence on the PN uptake. Considering as suitable radiotracer performance: high PN uptake and extraction, better combinations were 0.05 nmol/50 mu l, 0.135 nmo1/100 mu l, 0.22/50 mu l.Conclusion: Suitable performances could be reached by proper combinations of dose, injection volume and concentration for a specific radiotracer used in sentinel lymph node detection. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved. en
dc.description.sponsorship National Commission for Nuclear Energy (CNEN, São Paulo, Brazil)
dc.description.sponsorship Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorship International Atomic Energy Agency (IAEA, Vienna, Austria)
dc.description.sponsorship Covidien
dc.description.sponsorship Guerbet
dc.format.extent 145-153
dc.language.iso eng
dc.publisher Elsevier B.V.
dc.relation.ispartof Nuclear Medicine and Biology
dc.rights Acesso aberto
dc.subject Sentinel lymph node detection en
dc.subject Technetium-99m en
dc.subject Tissue-specific radiopharmaceutical en
dc.subject Dosage en
dc.subject Injected volume en
dc.title Combining dose and injection volume for good performance of a specific radiopharmaceutical for sentinel node detection en
dc.type Artigo
dc.rights.license http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institution Inst Energet & Nucl Res
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Inst Energet & Nucl Res, Radiopharm Ctr, BR-05508000 São Paulo, Brazil
dc.description.affiliation Universidade Federal de São Paulo, Fac Med, BR-04020041 São Paulo, SP, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Fac Med, BR-04020041 São Paulo, SP, Brazil
dc.identifier.file WOS000298936200016.pdf
dc.identifier.doi 10.1016/j.nucmedbio.2011.07.004
dc.description.source Web of Science
dc.identifier.wos WOS:000298936200016



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