Combining dose and injection volume for good performance of a specific radiopharmaceutical for sentinel node detection

Combining dose and injection volume for good performance of a specific radiopharmaceutical for sentinel node detection

Author Fernandez Nunez, Eutimio Gustavo Google Scholar
Oliveira, Érica Aparecida de Google Scholar
Silva, Natanael Gomes da Google Scholar
Oliveira Filho, Renato Santos de Autor UNIFESP Google Scholar
Institution Inst Energet & Nucl Res
Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction: the aim of this work was to quantify the effects of injection volume at different technetium-99m specific radiotracer doses on its lymphatic movement in animal model.Procedures: Effects of injection volume (50, 100 mu l) at different doses (0.05, 0.135, 0.22 nmol) on popliteal node (PN) detection were studied in rats. the radiotracer under study was (99m)Technetium-cysteine-mannose-dextran conjugate (30 kDa).Results: At 0.05 nmol dose, higher PN uptake was observed at 50 mu l injection volume (2.6 fold increase). Conversely, at 0.135 nmol dose, an increase of radiotracer retention in PN was achieved at 100 mu l volume, 78% higher than 50 mu l. However, at 0.22 nmol close, the injection volume changes did not influence on the PN uptake. Considering as suitable radiotracer performance: high PN uptake and extraction, better combinations were 0.05 nmol/50 mu l, 0.135 nmo1/100 mu l, 0.22/50 mu l.Conclusion: Suitable performances could be reached by proper combinations of dose, injection volume and concentration for a specific radiotracer used in sentinel lymph node detection. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
Keywords Sentinel lymph node detection
Technetium-99m
Tissue-specific radiopharmaceutical
Dosage
Injected volume
Language English
Sponsor National Commission for Nuclear Energy (CNEN, São Paulo, Brazil)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
International Atomic Energy Agency (IAEA, Vienna, Austria)
Covidien
Guerbet
Date 2012-01-01
Published in Nuclear Medicine and Biology. New York: Elsevier B.V., v. 39, n. 1, p. 145-153, 2012.
ISSN 0969-8051 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 145-153
Origin http://dx.doi.org/10.1016/j.nucmedbio.2011.07.004
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000298936200016
URI http://repositorio.unifesp.br/handle/11600/34341

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