Effect of incoherent LED radiation on third-degree burning wounds in rats

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dc.contributor.author Fiorio, Franciane B.
dc.contributor.author Silveira, Landulfo
dc.contributor.author Munin, Gberto
dc.contributor.author Lima, Carlos Jose de
dc.contributor.author Fernandes, Kristianne P. S.
dc.contributor.author Mesqui Ta-Ferrari, Raquel Agnelli
dc.contributor.author Carvalho, Paulo de Tarso C. de
dc.contributor.author Brandao Lopes-Martins, Rodrigo Alvaro
dc.contributor.author Aimbire, Flavio [UNIFESP]
dc.contributor.author Carvalho, Regiane Albertini de
dc.date.accessioned 2016-01-24T14:17:33Z
dc.date.available 2016-01-24T14:17:33Z
dc.date.issued 2011-12-01
dc.identifier http://dx.doi.org/10.3109/14764172.2011.630082
dc.identifier.citation Journal of Cosmetic and Laser Therapy. London: Informa Healthcare, v. 13, n. 6, p. 315-322, 2011.
dc.identifier.issn 1476-4172
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34325
dc.description.abstract The main physiological characteristics in a burn process are the increase of the capillary permeability and the occurrence of edema and exudation. Light-emitting diode (LED) has been proposed as treatment of burning. This study investigated the effects of LED on the repair process of rat skin submitted to a third-degree burning. the lesions were produced on the dorsal surface of male Wistar rats. Animals were divided into 4 groups (n = 6) as follows: L1 and L2 groups as LED-treated burned rats, and received LED therapy along 7 and 15 days with 48 hours intervals, respectively; C1 and C2 groups as control, non-treated burned rats. A red LED (640 nm, 30 mW) operating with a fluence of 4 J/cm(2) was used. the wound area was measured daily after irradiation. Animals were euthanized at the 8th and 16th days after burning, and the wound fragment was submitted to histology. the inflammatory cells as well as the damaged area at the 8th day after burns were significantly lower for the LED-treated group when compared to control. Furthermore, the LED phototherapy effect on cellular migration was even more pronounced at the 16th day. Our results indicated that the treatment with a LED system was clearly effective in reducing the number of inflammatory cells and improving the healing process in an experimental model of third-degree burnings. en
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent 315-322
dc.language.iso eng
dc.publisher Informa Healthcare
dc.relation.ispartof Journal of Cosmetic and Laser Therapy
dc.rights Acesso restrito
dc.subject epithelium en
dc.subject histology en
dc.subject inflammatory cells en
dc.subject phototherapy en
dc.subject rat en
dc.subject tissue damage en
dc.subject wound healing en
dc.title Effect of incoherent LED radiation on third-degree burning wounds in rats en
dc.type Artigo
dc.rights.license http://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Chapeco Univ UNOCHAPEC
dc.contributor.institution Camilo Castelo Branco Univ UNICASTELO
dc.contributor.institution Nove Julho Univ UNINOVE
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo, Dept Sci & Technol, Unifesp, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.affiliation Chapeco Univ UNOCHAPEC, Hlth Sci Ctr, Chapeco, SC, Brazil
dc.description.affiliation Camilo Castelo Branco Univ UNICASTELO, Inst Biomed Engineer, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliation Nove Julho Univ UNINOVE, Dept Rehabil Sci, São Paulo, Brazil
dc.description.affiliation Univ São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, Dept Sci & Technol, Unifesp, BR-12231280 Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipID FAPESP: 2007/02596-7
dc.identifier.doi 10.3109/14764172.2011.630082
dc.description.source Web of Science
dc.identifier.wos WOS:000297116900010



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