Effect of incoherent LED radiation on third-degree burning wounds in rats

Effect of incoherent LED radiation on third-degree burning wounds in rats

Author Fiorio, Franciane B. Google Scholar
Silveira, Landulfo Google Scholar
Munin, Gberto Google Scholar
Lima, Carlos Jose de Google Scholar
Fernandes, Kristianne P. S. Google Scholar
Mesqui Ta-Ferrari, Raquel Agnelli Google Scholar
Carvalho, Paulo de Tarso C. de Google Scholar
Brandao Lopes-Martins, Rodrigo Alvaro Google Scholar
Aimbire, Flavio Autor UNIFESP Google Scholar
Carvalho, Regiane Albertini de Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Chapeco Univ UNOCHAPEC
Camilo Castelo Branco Univ UNICASTELO
Nove Julho Univ UNINOVE
Universidade de São Paulo (USP)
Abstract The main physiological characteristics in a burn process are the increase of the capillary permeability and the occurrence of edema and exudation. Light-emitting diode (LED) has been proposed as treatment of burning. This study investigated the effects of LED on the repair process of rat skin submitted to a third-degree burning. the lesions were produced on the dorsal surface of male Wistar rats. Animals were divided into 4 groups (n = 6) as follows: L1 and L2 groups as LED-treated burned rats, and received LED therapy along 7 and 15 days with 48 hours intervals, respectively; C1 and C2 groups as control, non-treated burned rats. A red LED (640 nm, 30 mW) operating with a fluence of 4 J/cm(2) was used. the wound area was measured daily after irradiation. Animals were euthanized at the 8th and 16th days after burning, and the wound fragment was submitted to histology. the inflammatory cells as well as the damaged area at the 8th day after burns were significantly lower for the LED-treated group when compared to control. Furthermore, the LED phototherapy effect on cellular migration was even more pronounced at the 16th day. Our results indicated that the treatment with a LED system was clearly effective in reducing the number of inflammatory cells and improving the healing process in an experimental model of third-degree burnings.
Keywords epithelium
histology
inflammatory cells
phototherapy
rat
tissue damage
wound healing
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2007/02596-7
Date 2011-12-01
Published in Journal of Cosmetic and Laser Therapy. London: Informa Healthcare, v. 13, n. 6, p. 315-322, 2011.
ISSN 1476-4172 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 315-322
Origin http://dx.doi.org/10.3109/14764172.2011.630082
Access rights Closed access
Type Article
Web of Science ID WOS:000297116900010
URI http://repositorio.unifesp.br/handle/11600/34325

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