Cytogenetic studies in peripheral blood of bovines afflicted by papillomatosis

Cytogenetic studies in peripheral blood of bovines afflicted by papillomatosis

Author Melo, T. C. Google Scholar
Diniz, N. Google Scholar
Campos, S. R. C. Google Scholar
Ferraz, O. P. Google Scholar
Lindsey, C. J. Autor UNIFESP Google Scholar
Rieger, T. T. Google Scholar
Becak, W. Google Scholar
Stocco, R. C. Google Scholar
Institution Inst Butantan
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Pernambuco (UFPE)
Abstract Ten types of bovine papillomavirus (BPV) have been described and there are reports of viral transmission via blood. the presence of viral DNA in lymphocytes was described to be associated with chromosome instability in these cells. This study presents an evaluation of chromosome instability in short-term peripheral lymphocyte cultures from cows presenting skin papillomatosis, compared with asymptomatic infected animals and non-infected healthy bovines. in a total of 2203 cells, 918 (42%) showed at least one chromosome aberration: 42.7 ( +/- 7.8) in animals with papillomatosis (BPV + W), 40.2 (+/- 11) in asymptomatic animals (BPV - W) and 4 (+/- 2) in control animals. Significant differences were found between the infected group (with or without symptoms) and the control group (P < 0.0001). the increased frequencies of chromosome aberrations suggest an interaction between the virus and host cell chromatin.
Keywords BPV
chromatin
chromosome aberrations
papillomatosis
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
DECIT/MS
Fundo Setorial de Biotecnologia (CT-Biotecnologia)
Saude (CT-Saude)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 554816/2006-7
FAPESP: 559043/2008-2
FAPESP: 2006/02439-6
Date 2011-12-01
Published in Veterinary and Comparative Oncology. Malden: Wiley-Blackwell, v. 9, n. 4, p. 269-274, 2011.
ISSN 1476-5810 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 269-274
Origin http://dx.doi.org/10.1111/j.1476-5829.2011.00263.x
Access rights Closed access
Type Article
Web of Science ID WOS:000297930600004
URI http://repositorio.unifesp.br/handle/11600/34317

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