Weekly Iron Supplementation for the Prevention of Anemia in Pre-school Children: A Randomized, Double-blind, Placebo-controlled Trial

Weekly Iron Supplementation for the Prevention of Anemia in Pre-school Children: A Randomized, Double-blind, Placebo-controlled Trial

Author Nogueira Arcanjo, Francisco Placido Google Scholar
Arcanjo, Cecilia Costa Google Scholar
Silverio Amancio, Olga Maria Autor UNIFESP Google Scholar
Pellegrini Braga, Josefina Aparecida Autor UNIFESP Google Scholar
Madeiro Leite, Alvaro Jorge Google Scholar
Institution Univ Fed Ceara
Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: This study analyses the impact of weekly iron supplementation with ferrous sulphate heptahydrate (FeSO4) in 5-year-olds compared with placebo, on hemoglobin (Hb) and hematocrit (Ht) values and anemia. Design: the study concerns a cluster-randomized, placebo-controlled double-blind trial. Intervention participants received 50 mg elemental iron for 14 weeks. Setting: the study population comprised pre-school children (n = 135) from one randomly chosen public school in the northeast of Brazil. Subjects: Participants were 5-year-old students from a public school. Results: Mean Hb and Ht values increased after iron supplementation, with p < 0.0001. There was no statistically significant increase in the placebo group. After intervention, anemia prevalence reduced only in the intervention group, from 48.0% to 26.0%. Conclusions: Weekly iron supplementation was effective in reducing anemia in 5-year-olds.
Keywords iron
supplementation
pre-school children
hemoglobins
anemia
Language English
Sponsor Santa Casa de Misericordia de Sobral Hospital, Sobral, CE, Brazil
Secretariat of Education and Secretariat of Health at the Municipal City Hall-Sobral-CE
Date 2011-12-01
Published in Journal of Tropical Pediatrics. Oxford: Oxford Univ Press, v. 57, n. 6, p. 433-438, 2011.
ISSN 0142-6338 (Sherpa/Romeo, impact factor)
Publisher Oxford Univ Press
Extent 433-438
Origin http://dx.doi.org/10.1093/tropej/fmq119
Access rights Closed access
Type Article
Web of Science ID WOS:000297574000006
URI http://repositorio.unifesp.br/handle/11600/34309

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