Neurocutaneous melanosis: Follow-up and literature review

Neurocutaneous melanosis: Follow-up and literature review

Author Scattolin, M. A. A. Autor UNIFESP Google Scholar
Lin, J. Autor UNIFESP Google Scholar
Peruchi, M. M. Google Scholar
Rocha, A. J. Google Scholar
Masruha, M. R. Autor UNIFESP Google Scholar
Vilanova, L. C. P. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Santa Casa de Misericordia São Paulo
Abstract Neurocutaneous melanosis is a rare, congenital, non-inherited syndrome characterized by numerous and/or large congenital nevi with intracranial leptomeningeal melanocytosis. This report describes two patients, presenting with a giant congenital nevus involving, a major portion of the posterior trunk with satellite congenital nevi scattered all over the body, who developed seizures at 4 and 6 months of age, respectively. Changes in follow-up magnetic resonance (MR) examinations over an 8-year period were seen in case 1, while parenchymal melanocytic accumulation was reported in the region of the amygdala in case 2. These cases emphasize that neurocutaneous melanosis should be suspected in patients with giant congenital nevus with or without neurological symptoms. Also, neuroaxial MR screening should be performed in all cases and, ideally, before myelination of the brain to provide the highest sensitivity for detecting melanin deposits in the leptomeninges. (C) 2011 Elsevier Masson SAS. All rights reserved.
Keywords Neurocutaneous melanosis
Giant melanocytic nevus
Children
Language English
Date 2011-12-01
Published in Journal of Neuroradiology. Moulineaux Cedex 9: Masson Editeur, v. 38, n. 5, p. 313-318, 2011.
ISSN 0150-9861 (Sherpa/Romeo, impact factor)
Publisher Masson Editeur
Extent 313-318
Origin http://dx.doi.org/10.1016/j.neurad.2011.02.007
Access rights Closed access
Type Review
Web of Science ID WOS:000298075500008
URI http://repositorio.unifesp.br/handle/11600/34298

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