Hormonal appetite control is altered by shift work: a preliminary study

Hormonal appetite control is altered by shift work: a preliminary study

Author Crispim, Cibele Aparecida Autor UNIFESP Google Scholar
Waterhouse, Jim Maris Google Scholar
Dâmaso, Ana Raimunda Autor UNIFESP Google Scholar
Zimberg, Iona Zalcman Autor UNIFESP Google Scholar
Padilha, Heloisa Vidigal Guarita Autor UNIFESP Google Scholar
Oyama, Lila Missae Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Uberlândia (UFU)
Liverpool John Moores Univ
Abstract Shift work has been associated with a higher propensity for developing nutritional problems and obesity. However, the possible changes in leptin and ghrelin (2 hormones that contribute importantly to the central regulation of food intake) concentrations in this population are poorly described. the objective of the study was to evaluate the daily concentrations of leptin, nonacylated ghrelin, and acylated ghrelin and the appetite ratings in men working different shift schedules. Daily concentrations of nonacylated ghrelin, acylated ghrelin, and leptin and appetite were measured in 3 groups of subjects: workers on fixed night shifts (n = 9), fixed early morning shifts (n = 6), and fixed day shifts (n = 7). Appetite was evaluated by a validated questionnaire. Blood samples were collected every 4 hours over the course of 24 hours for a total of 6 samples. When comparing the 3 groups, leptin concentrations at 8:00 AM and 4:00 PM for those workers on the day shift were significantly lower than for those on the early morning shift; and concentrations at noon for those workers on the day shift were significantly lower than for those on the night shift. Nonacylated and acylated ghrelin concentrations were significantly lower for those workers on the early morning shift than for those on the day shift. in general, appetite was the lowest in those working the early morning shift. Shift workers on the early morning shift have lower appetites and concentrations of leptin and nonacylated and acylated ghrelin than the workers on other shifts. Further studies are required to better understand the detailed needs of these individuals. (C) 2011 Elsevier Inc. All rights reserved.
Language English
Sponsor AFIP
Sleep Institute
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Centro de Estudo Multidisciplinar em Sonolencia e Acidentes (CEMSA)
Grant number FAPESP: 998/14303-3
Date 2011-12-01
Published in Metabolism-clinical and Experimental. Philadelphia: W B Saunders Co-Elsevier Inc, v. 60, n. 12, p. 1726-1735, 2011.
ISSN 0026-0495 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 1726-1735
Origin http://dx.doi.org/10.1016/j.metabol.2011.04.014
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000297528400012
URI http://repositorio.unifesp.br/handle/11600/34245

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