Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats

Effects of antipsychotics and amphetamine on social behaviors in spontaneously hypertensive rats

Author Calzavara, Mariana Bendlin Autor UNIFESP Google Scholar
Levin, Raquel Autor UNIFESP Google Scholar
Medrano, Wladimir Agostini Autor UNIFESP Google Scholar
Almeida, Valeria Autor UNIFESP Google Scholar
Frois Sampaio, Antonio Pereira Autor UNIFESP Google Scholar
Barone, Lucas Cerqueira Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Abilio, Vanessa Costhek Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We have recently reported that spontaneously hypertensive rats (SHRs) exhibit a deficit in contextual fear conditioning that is specifically reversed by antipsychotic and potentiated by psychostimulants and other manipulations thought to produce schizophrenia-like states in rodents. Based on these findings, we suggested that this deficit in fear conditioning could be used as an experimental model of emotional processing impairments observed in schizophrenia. This strain has also been suggested as a model by which to study attention deficit/hyperactivity disorder (ADHD). Considering that schizophrenia and ADHD are both characterized by poor social function, this study aimed to investigate possible behavioral deficits of SHRs in a social context. Furthermore, we sought to examine the effects of typical and atypical antipsychotics (used for the treatment of schizophrenia) and a psychostimulant (used to treat ADHD) on these behaviors. Pairs of unfamiliar rats of the same or different (i.e., Wistar) strains were treated with one of the aforementioned drugs and placed in an open-field for 10 min. During this time, social behaviors, locomotion and rearing frequencies were scored. Atypical antipsychotics increased social interaction in Wistar rats (WRs) and improved the deficit in social interaction exhibited by SHRs. in addition, the SHR group displayed hyperlocomotion that was attenuated by all antipsychotics (quetiapine and clozapine also decreased locomotion in WRs) and potentiated by amphetamine (which also increased locomotion in WRs). Our results reveal that the behavioral profile of the SHR group demonstrates that this strain can be a useful animal model to study several aspects of schizophrenia. (C) 2011 Elsevier B.V. All rights reserved.
Keywords SHR
Social interaction
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2011-11-20
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 225, n. 1, p. 15-22, 2011.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 15-22
Origin http://dx.doi.org/10.1016/j.bbr.2011.06.026
Access rights Closed access
Type Article
Web of Science ID WOS:000295766900003
URI http://repositorio.unifesp.br/handle/11600/34230

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