Increased dopamine transporter density in Parkinson's disease patients with social anxiety disorder

Increased dopamine transporter density in Parkinson's disease patients with social anxiety disorder

Author Moriyama, Tais S. Autor UNIFESP Google Scholar
Felicio, Andre C. Autor UNIFESP Google Scholar
Chagas, Marcos H. N. Google Scholar
Tardelli, Vitor S. Autor UNIFESP Google Scholar
Ferraz, Henrique Ballalai Autor UNIFESP Google Scholar
Tumas, Vitor Google Scholar
Amaro-Junior, Edson Google Scholar
Andrade, Luiz Augusto Franco de Autor UNIFESP Google Scholar
Crippa, Jose Alexandre Google Scholar
Bressan, Rodrigo A. Autor UNIFESP Google Scholar
Institution Hosp Israelita Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
CNPq
Abstract Social Anxiety Disorder (SAD) is more common among PD patients than in the general population. This association may be explained by psychosocial mechanisms but it is also possible that neurobiological mechanism underlying PD can predispose to SAD. the aim of this study was to investigate a possible dopaminergic mechanism involved in PD patients with SAD, by correlating striatal dopamine transporter binding potential (DAT-BP) with intensity of social anxiety symptoms in PD patients using SPECT with TRODAT-1 as the radiopharmaceutical. Eleven PD patients with generalized SAD and 21 PD patients without SAD were included in this study; groups were matched for age, gender, disease duration and disease severity. SAD diagnosis was determined according to DSM IV criteria assessed with SCID-I and social anxiety symptom severity with the Brief Social Phobia Scale (BSPS). Demographic and clinical data were also collected. DAT-BP was significantly correlated to scores on BSPS for right putamen (r = 0.37, p = 0.04), left putamen (r = 0.43, p = 0.02) and left caudate (r = 0.39, p = 0.03). No significant correlation was found for the right caudate (r = 0.23, p = 0.21). This finding may reinforce the hypothesis that dopaminergic dysfunction might be implicated in the pathogenesis of social anxiety in PD. (C) 2011 Elsevier B.V. All rights reserved.
Keywords Social anxiety disorder
Social phobia
Parkinson's disease
Dopamine transporter
TRODAT-1
SPECT
Language English
Date 2011-11-15
Published in Journal of the Neurological Sciences. Amsterdam: Elsevier B.V., v. 310, n. 1-2, p. 53-57, 2011.
ISSN 0022-510X (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 53-57
Origin http://dx.doi.org/10.1016/j.jns.2011.06.056
Access rights Closed access
Type Article
Web of Science ID WOS:000296927500014
URI http://repositorio.unifesp.br/handle/11600/34224

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