Acute effects of donepezil in healthy young adults underline the fractionation of executive functioning

Acute effects of donepezil in healthy young adults underline the fractionation of executive functioning

Author Ginani, G. E. Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Bueno, O. F. A. Autor UNIFESP Google Scholar
Pradella-Hallinan, M. Autor UNIFESP Google Scholar
Rusted, J. Google Scholar
Pompeia, S. Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Univ Sussex
Abstract The cholinergic system is involved in the modulation of both bottom-up and top-down attentional control. Top-down attention engages multiple executive control processes, but few studies have investigated whether all or selective elements of executive functions are modulated by the cholinergic system. To investigate the acute effects of the pro-cholinergic donepezil in young, healthy volunteers on distinct components of executive functions we conducted a double-blind, placebo-controlled, independent-groups design study including 42 young healthy male participants who were randomly assigned to one of three oral treatments: glucose (placebo), donepezil 5 mg or donepezil 7.5 mg. the test battery included measures of different executive components (shifting, updating, inhibition, dual-task performance, planning, access to long-term memory), tasks that evaluated arousal/vigilance/visuomotor performance, as well as functioning of working memory subsidiary systems. Donepezil improved sustained attention, reaction times, dual-task performance and the executive component of digit span. the positive effects in these executive tasks did not correlate with arousal/visuomotor/vigilance measures. Among the various executive domains investigated donepezil selectively increased dual-task performance in a manner that could not be ascribed to improvement in arousal/vigilance/visuomotor performance nor working memory slave systems. Other executive tasks that rely heavily on visuospatial processing may also be modulated by the cholinergic system.
Keywords Attention
executive functions
working memory
Language English
Sponsor Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Grant number FAPESP: 1998/14303-3
Date 2011-11-01
Published in Journal of Psychopharmacology. London: Sage Publications Ltd, v. 25, n. 11, p. 1508-1516, 2011.
ISSN 0269-8811 (Sherpa/Romeo, impact factor)
Publisher Sage Publications Ltd
Extent 1508-1516
Access rights Closed access
Type Article
Web of Science ID WOS:000297943900009

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