A cross-sectional study of umbilical cord blood donor profiles and their influence on umbilical cord blood collection in a Brazilian hospital

A cross-sectional study of umbilical cord blood donor profiles and their influence on umbilical cord blood collection in a Brazilian hospital

Author Santos, Sandra Valeria Google Scholar
Marti, Luciana Google Scholar
Feitosa Ribeiro, Andreza Alice Google Scholar
Conti, Fabiana Google Scholar
Barros, Sonia Maria Autor UNIFESP Google Scholar
Institution Hosp Israelita Albert Einstein
Inst Israelita Ensino & Pesquisa Albert Einstein
Universidade Federal de São Paulo (UNIFESP)
Abstract Background aims. Umbilical cord blood (UCB) cells are a new alternative to bone marrow source for hematopoietic stem cell transplantation and their use has increased in the last decade. Thus efforts are being made to improve the umbilical cord blood unit's quality. Besides compatibility, other factors, such as the total nucleated cell (TNC) count and the percentage of CD34(+) cells in the product, are very important for a successful transplant outcome. Our aim was to describe our donor population and assess the best cord blood collection technique at Hospital Israelita Albert Einstein's cord blood bank (São Paulo, Brazil). Methods. This was a retrospective study in which all analyses were performed simultaneously. A Student's t-test was used for qualitative variables for non-matched samples. for qualitative analyses, we used either the chi-square test or the exact Fisher's test. Results. the stratification of the population characteristics allowed us to determine which ones had an impact on unit volume, TNC count and percentage of CD34(+) cells. A significant correlation was observed between donor characteristics and the quality of UCB units as related to maternal and gestational age, type of pregnancy, route of delivery, cord blood collection technique and birth weight. Conclusions. We found that cord blood collection technique and newborn weight were significantly correlated with the TNC content. the collection technique used at our institution significantly improved the UCB unit volume and consequently the TNC count. Some findings, such as the impact of maternal age and newborn weight, have led us to re-evaluate our protocol in order to achieve better results.
Keywords CD34(+)
total nucleated cells
umbilical cord blood cells
Language English
Date 2011-10-01
Published in Cytotherapy. London: Informa Healthcare, v. 13, n. 9, p. 1120-1127, 2011.
ISSN 1465-3249 (Sherpa/Romeo, impact factor)
Publisher Informa Healthcare
Extent 1120-1127
Origin http://dx.doi.org/10.3109/14653249.2011.598145
Access rights Closed access
Type Article
Web of Science ID WOS:000294904300010
URI http://repositorio.unifesp.br/handle/11600/34137

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