Acute Hepatitis C in Brazil: Results of a National Survey

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dc.contributor.author Paiva Ferreira, Adalgisa de Souza
dc.contributor.author Perez, Renata de Mello
dc.contributor.author Gomes Ferraz, Maria Lucia [UNIFESP]
dc.contributor.author Lewis-Ximenez, Lia Laura
dc.contributor.author Pereira, Joao Luis
dc.contributor.author Lerias de Almeida, Paulo Roberto
dc.contributor.author Mattos, Angelo Alves de
dc.contributor.author Acute Hepatitis C Study Grp Brazil
dc.date.accessioned 2016-01-24T14:17:15Z
dc.date.available 2016-01-24T14:17:15Z
dc.date.issued 2011-10-01
dc.identifier http://dx.doi.org/10.1002/jmv.22175
dc.identifier.citation Journal of Medical Virology. Malden: Wiley-Blackwell, v. 83, n. 10, p. 1738-1743, 2011.
dc.identifier.issn 0146-6615
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/34084
dc.description.abstract The incidence of acute hepatitis C has decreased in the world. However, new cases are still reported. the objective of this study was to obtain data of acute hepatitis C in Brazil and to identify risk factors of transmission, diagnostic criteria, clinical presentation, evolution, and treatment. A questionnaire was sent to all members of the Brazilian Society of Hepatology. Sixteen centers participated with a total of 170 cases between 2000 and 2008. Among them, 37 had chronic renal failure on hemodialysis and were evaluated separately. the main diagnostic criterion in non-uremic patients was ALT (alanine aminotransferase) elevation associated with risk factors. in patients with chronic renal failure, anti-hepatitis C virus (HCV) sero-conversion was the most frequent criterion. Among the 133 non-uremic patients the main risk factors were hospital procedures, whereas in hemodialysis patients, dialysis was the single risk factor in 95% of the cases. Jaundice was more frequent in non-uremic patients (82% vs. 13%; P < 0.001) and ALT levels were higher in these individuals (P < 0.001). Spontaneous clearance was more frequent in non-uremic patients (51% vs. 3%; P < 0.001). Sixty-five patients were treated: 39 non-urennic patients and 26 on dialysis. Sustained virological response rates were 60% for non-uremic and 58% for uremic patients (P = 0.98). There was no association of these rates with the study variables. These findings show that cases of acute hepatitis C are still occurring and have been related predominantly to hospital procedures. Measures to prevent nosocomial transmission should be adopted rigorously and followed to minimize this important source of infection observed in this survey. J. Med. Virol. 83:1738-1743, 2011. (C) 2011 Wiley-Liss, Inc. J. Med. en
dc.format.extent 1738-1743
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Journal of Medical Virology
dc.rights Acesso restrito
dc.subject acute hepatitis C en
dc.subject Brazil en
dc.subject epidemiology en
dc.subject HCV en
dc.subject risk factors en
dc.title Acute Hepatitis C in Brazil: Results of a National Survey en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Univ Fed Maranhao
dc.contributor.institution Universidade Federal do Rio de Janeiro (UFRJ)
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Osvaldo Cruz Fdn
dc.contributor.institution Gen Hosp Bonsucesso
dc.contributor.institution Nossa Senhora Conceicao Hosp
dc.contributor.institution Fed Fdn Sch Med Sci
dc.description.affiliation Univ Fed Maranhao, Sao Luis, MA, Brazil
dc.description.affiliation Univ Fed Rio de Janeiro, Rio de Janeiro, Brazil
dc.description.affiliation Universidade Federal de São Paulo, São Paulo, Brazil
dc.description.affiliation Osvaldo Cruz Fdn, Rio de Janeiro, Brazil
dc.description.affiliation Gen Hosp Bonsucesso, Rio de Janeiro, Brazil
dc.description.affiliation Nossa Senhora Conceicao Hosp, Porto Alegre, RS, Brazil
dc.description.affiliation Fed Fdn Sch Med Sci, Porto Alegre, RS, Brazil
dc.description.affiliationUnifesp Universidade Federal de São Paulo, São Paulo, Brazil
dc.identifier.doi 10.1002/jmv.22175
dc.description.source Web of Science
dc.identifier.wos WOS:000293985900009



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