Acute glucocorticoid effects on the multicomponent model of working memory

Acute glucocorticoid effects on the multicomponent model of working memory

Author Vaz, Leonardo Jose Autor UNIFESP Google Scholar
Pradella-Hallinan, Marcia Autor UNIFESP Google Scholar
Amodeo Bueno, Orlando Francisco Autor UNIFESP Google Scholar
Pompeia, Sabine Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective in comparison with basal physiological levels, acute, high levels of cortisol affect learning and memory. Despite reports of cortisol-induced episodic memory effects, no study has used a comprehensive battery of tests to evaluate glucocorticoid effects on the multicomponent model of working memory. Here, we report the results of a double-blind, placebo-controlled, between-subjects study.Methods Twenty healthy young men were randomly assigned to either acute cortisol (30 mg hydrocortisone) or placebo administration. Participants were subjected to an extensive cognitive test battery that evaluated all systems of the multicomponent model of working memory, including various executive domains (shifting, updating, inhibition, planning and access to long-term memory).Results Compared with placebo, hydrocortisone administration increased cortisol blood levels and impaired working memory in storage of multimodal information in the episodic buffer and maintenance/reverberation of information in the phonological loop. Hydrocortisone also decreased performance in planning and inhibition tasks, the latter having been explained by changes in storage of information in working memory.Conclusions Thus, hydrocortisone acutely impairs various components of working memory, including executive functioning. This effect must be considered when administering similar drugs, which are widely used for the treatment of many clinical disorders. Copyright (C) 2011 John Wiley & Sons, Ltd.
Keywords glucocorticoid
hydrocortisone
memory
working memory
cognition
executive function
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Associacao Fundo de Incentivo a Pesquisa (AFIP)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 2005/00362-3
Date 2011-10-01
Published in Human Psychopharmacology-clinical and Experimental. Malden: Wiley-Blackwell, v. 26, n. 7, p. 477-487, 2011.
ISSN 0885-6222 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 477-487
Origin http://dx.doi.org/10.1002/hup.1230
Access rights Closed access
Type Article
Web of Science ID WOS:000297410300005
URI http://repositorio.unifesp.br/handle/11600/34083

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