Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus

Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus

Author Rosim, Fernanda Elisa Autor UNIFESP Google Scholar
Persike, Daniele Suzete Autor UNIFESP Google Scholar
Nehlig, Astrid Google Scholar
Amorim, Rebeca Padrão Autor UNIFESP Google Scholar
Oliveira, Daniela Mara de Google Scholar
Fernandes, Maria Jose da Silva Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
INSERM
Universidade de Brasília (UnB)
Abstract Aiming at a better understanding of the role of A(2A) in temporal lobe epilepsy (TLE), we characterized the effects of the A(2A) antagonist SCH58261 (7-(2-phenylethyl)-5-amino-2(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c] pyrimidine) on seizures and neuroprotection in the pilocarpine model. the effects of SCH58261 were further analyzed in combination with the A(1) agonist R-Pia (R(-)-N-6-(2)-phenylisopropyl adenosine). Eight groups were studied: pilocarpine (Pilo), SCH + Pilo, R-Pia + Pilo, R-Pia + SCH + Pilo, Saline, SCH + Saline, R-Pia + Saline, and R-Pia + SCH + Saline. the administration of SCH58261, R-Pia, and R-Pia + SCH58261 prior to pilocarpine increased the latency to SE, and decreased either the incidence of or rate of mortality from SE compared with controls. Administration of R-Pia and R-Pia + SCH58261 prior to pilocarpine reduced the number of Fluoro-Jade B-stained cells in the hippocampus and piriform cortex when compared with control. This study showed that pretreatment with R-Pia and SCH58261 reduces seizure occurrence, although only R-Pia has neuroprotective properties. Further studies are needed to clarify the neuroprotective role of A(2A) in TLE. (C) 2011 Elsevier Inc. All rights reserved.
Keywords Adenosine
A(2A) receptor
SCH58261
A(1) receptor
Neuroprotection
Pilocarpine
Status epilepticus
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Date 2011-10-01
Published in Epilepsy & Behavior. San Diego: Academic Press Inc Elsevier Science, v. 22, n. 2, p. 207-213, 2011.
ISSN 1525-5050 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 207-213
Origin http://dx.doi.org/10.1016/j.yebeh.2011.07.004
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000295706800010
URI http://repositorio.unifesp.br/handle/11600/34069

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