Neonatal exposure to constant light prevents anhedonia-like behavior induced by constant light exposure in adulthood

Neonatal exposure to constant light prevents anhedonia-like behavior induced by constant light exposure in adulthood

Author Martynhak, Bruno J. Google Scholar
Correia, Diego Google Scholar
Morais, Livia H. Google Scholar
Araujo, Paula Autor UNIFESP Google Scholar
Andersen, Monica L. Autor UNIFESP Google Scholar
Lima, Marcelo M. S. Google Scholar
Louzada, Fernando M. Google Scholar
Andreatini, Roberto Google Scholar
Institution Univ Fed Parana
Universidade Federal de São Paulo (UNIFESP)
Abstract Depressive episodes are associated with disturbances in circadian rhythms, and constant illumination has been reported to induce depressive-like behavior in rodents. Rats kept in constant darkness express the endogenous circadian rhythm, and most animals under constant light conditions lose circadian locomotor rhythmicity. Exposure to constant light in rats during lactation was reported to prevent this loss of circadian rhythm in adulthood. Thus, the aim of the present study was to verify whether exposure to constant light during lactation prevents anhedonia-like behavior induced by constant light in adult rats. in experiment 1, we replicated the anhedonia-like effects of constant light in adult male rats. We showed that this effect is reversed by imipramine treatment in the drinking water. in experiment 2, we subjected rats to constant darkness (neonatal-DD), constant light (neonatal-LL) or to normal light/dark cycle (neonatal-LD) during the neonatal phase and evaluated them after constant light exposure in adulthood. the group exposed to constant light during the neonatal phase did not reduce their sucrose preference and exhibited greater locomotor activity than the other groups. the neonatal-DD group exhibited decreased sucrose preference earlier than controls and had higher serum corticosterone concentrations. Prevention of arrhythymicity might protect neonatal-LL rats from anhedonia-like behavior induced by constant light, whereas constant darkness during the neonatal phase rendered the neonatal-DD group more susceptible to depressive-like behavior. These results corroborate with the literature data indicating that circadian disruption may contribute in mood disorders and that early life stress can influence stress responsivity in adulthood. (C) 2011 Elsevier B.V. All rights reserved.
Keywords Depressive behavior
Sucrose preference test
Circadian rhythms
Constant light
Neonatal stress
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Date 2011-09-12
Published in Behavioural Brain Research. Amsterdam: Elsevier B.V., v. 222, n. 1, p. 10-14, 2011.
ISSN 0166-4328 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 10-14
Access rights Closed access
Type Article
Web of Science ID WOS:000291418400002

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