Chronic use of indinavir in albino rat pregnancy (Rattus norvegicus albinus, Rodentia, Mammalia): Biological assay

Chronic use of indinavir in albino rat pregnancy (Rattus norvegicus albinus, Rodentia, Mammalia): Biological assay

Author Quintino, Marisa Pascale Autor UNIFESP Google Scholar
Nakamura, Mary Uchiyama Autor UNIFESP Google Scholar
Simoes, Manuel de Jesus Autor UNIFESP Google Scholar
Araujo Junior, Edward Autor UNIFESP Google Scholar
Oliveira Filho, Ricardo Martins de Autor UNIFESP Google Scholar
Torloni, Maria Regina Autor UNIFESP Google Scholar
Espiridião, Silvia Autor UNIFESP Google Scholar
Kulay Júnior, Luiz Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
ABC Fdn
Abstract Aim: Assess possible adverse effects of the chronic use of indinavir during pregnancy in a rat model.Methods: 40 pregnant EOM-1 albino rats were randomly allocated into four groups of 10 animals each: a control (Ctr) group (without any handling) and three experimental groups (Exp 1, Exp 2 e Exp 3) which received indinavir 9, 27 e 81 mg/kg, respectively). Rats were treated by gavage once daily. the treatment period extended from day 0 until the 20th day of pregnancy. Body weights were recorded on days 0, 7, 14 and 20. At term, the rats were sacrificed, and the implantation sites, number of live and dead fetuses and placentas, resorptions, fetal and placental weights were recorded. the fetuses were evaluated for external abnormalities under a stereomicroscope.Results: Weight gain during pregnancy did not differ significantly between the groups. Average weight gains between the 7th and 20th day were 7.95-42.70 g; 7.22-45.27 g; 7.12-46.26 g and 8.05-42.29 g in groups Ctr, Exp 1, Exp 2 and Exp 3, respectively. All other parameters assessed did not differ significantly between groups.Conclusions: Chronic use of various dosages of indinavir during pregnancy was not associated significant adverse outcomes.
Keywords biological assay
indinavir
pregnancy
rat
teratology
Language English
Date 2011-09-01
Published in Journal of Obstetrics and Gynaecology Research. Malden: Wiley-Blackwell, v. 37, n. 9, p. 1212-1215, 2011.
ISSN 1341-8076 (Sherpa/Romeo, impact factor)
Publisher Wiley-Blackwell
Extent 1212-1215
Origin http://dx.doi.org/10.1111/j.1447-0756.2010.01504.x
Access rights Closed access
Type Article
Web of Science ID WOS:000295097300006
URI http://repositorio.unifesp.br/handle/11600/34030

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