Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats

Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats

Author Lira, Fabio Santos da Autor UNIFESP Google Scholar
Yamashita, Alex S. Google Scholar
Rosa, Jose C. Autor UNIFESP Google Scholar
Tavares, Fabio L. Google Scholar
Caperuto, Erico Google Scholar
Carnevali, Luiz C. Google Scholar
Pimentel, Gustavo Duarte Autor UNIFESP Google Scholar
Santos, Ronaldo V. T. Autor UNIFESP Google Scholar
Batista, Miguel L. Google Scholar
Laviano, Alessandro Google Scholar
Rossi-Fanelli, Filippo Google Scholar
Seelaender, Marilia Google Scholar
Institution Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Sapienza Univ Rome
Abstract Aim: We tested the effects of a cancer cachexia-anorexia sydrome upon the balance of anti and pro-inflammatory cytokines in the hypothalamus of sedentary or trained tumour-bearing (Walker-256 carcinosarcoma) rats.Methods: Animals were randomly assigned to a sedentary control (SC), sedentary tumour-bearing (ST), and sedentary pair-fed (SPF) groups or, exercised control (EC), exercised tumour-bearing (ET) and exercised pair-fed (EPF) groups. Trained rats ran on a treadmill (60%VO(2max)) for 60 min/d, 5 days/wk, for 8 wks. We evaluated food intake, leptin and cytokine (TNF-alpha, IL1 beta) levels in the hypothalamus.Results: the cumulative food intake and serum leptin concentration were reduced in ST compared to SC. Leptin gene expression in the retroperitoneal adipose tissue (RPAT) was increased in SPF in comparison with SC and ST, and in the mesenteric adipose tissue (MEAT) the same parameter was decreased in ST in relation to SC. Leptin levels in RPAT and MEAT were decreased in ST, when compared with SC. Exercise training was also able to reduce tumour weight when compared to ST group. in the hypothalamus, IL-1 beta and IL-10 gene expression was higher in ST than in SC and SPF. Cytokine concentration in hypothalamus was higher in ST (TNF-alpha and IL-1 beta, p < 0.05), compared with SC and SPF. These pro-inflammatory cytokines concentrations were restored to control values (p < 0.05), when the animals were submitted to endurance training.Conclusion: Cancer-induced anorexia leads towards a pro-inflammatory state in the hypothalamus, which is prevented by endurance training which induces an anti-inflammatory state, with concomitant decrease of tumour weight.
Keywords anorexia
cancer cachexia
hypothalamus
exercise training
cytokines
inflammation
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 04/11588-0
FAPESP: 05/01445-0
Date 2011-08-24
Published in Nutrition & Metabolism. London: Biomed Central Ltd, v. 8, 7 p., 2011.
ISSN 1743-7075 (Sherpa/Romeo, impact factor)
Publisher Biomed Central Ltd
Extent 7
Origin http://dx.doi.org/10.1186/1743-7075-8-60
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000299100200001
URI http://repositorio.unifesp.br/handle/11600/33965

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